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Editorial
. 2019 Jan 16;11(2):291-292.
doi: 10.18632/aging.101772.

Hormone therapy outcome in lymphedema

Barbara Garmy-Susini  1
Affiliations
Editorial

Hormone therapy outcome in lymphedema

Barbara Garmy-Susini. Aging (Albany NY). .
No abstract available

Keywords: estrogen; hormone therapy; lymphedema; menopause; tamoxifen.

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Figures

Figure 1
Figure 1
Tamoxifen treatment leads to lymphatic dysfunction and aggravates lymphedema. Tamoxifen inhibits estrogen binding to its receptor ERα on lymphatic endothelial cells to block both genomic and non-genomic pathways. After long-term delivery, the blockade of ERα by hormone therapy leads to lymphatic dilatation and leakage, the main features of lymphatic shape in lymphedema.
See this image and copyright information in PMC

Comment on

  • Lymphatic Vasculature Requires Estrogen Receptor-α Signaling to Protect From Lymphedema.
    Morfoisse F, Tatin F, Chaput B, Therville N, Vaysse C, Métivier R, Malloizel-Delaunay J, Pujol F, Godet AC, De Toni F, Boudou F, Grenier K, Dubuc D, Lacazette E, Prats AC, Guillermet-Guibert J, Lenfant F, Garmy-Susini B. Morfoisse F, et al. Arterioscler Thromb Vasc Biol. 2018 Jun;38(6):1346-1357. doi: 10.1161/ATVBAHA.118.310997. Epub 2018 Apr 12. Arterioscler Thromb Vasc Biol. 2018. PMID: 29650694

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