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Comment
. 2019 Jan 15;50(1):3-5.
doi: 10.1016/j.immuni.2018.12.030.

Coronin-1, King of Alloimmunity

Mandy L Ford  1
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Coronin-1, King of Alloimmunity

Mandy L Ford. Immunity. .
Free article

Abstract

Defining pathways that differentially regulate graft-reactive versus anti-microbial T cell responses could facilitate more precise manipulation of immune responses in the context of organ and tissue transplantation. Here, Jayachandran et al. (2019) identify a coronin-1-PDE4-cAMP axis that, when perturbed, results in the induction of transplantation tolerance while maintaining anti-microbial immunity.

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