Defining Dysbiosis in Inflammatory Bowel Disease
- PMID: 30650382
- DOI: 10.1016/j.immuni.2018.12.028
Defining Dysbiosis in Inflammatory Bowel Disease
Abstract
In this issue of Immunity, Britton et al. (2019) demonstrate that the colonization of germ-free mice with microbiotas from inflammatory bowel disease patients induces an altered ratio of RORγt+ regulatory T cells to T(h17) effector cells and recapitulates human disease severity in colitis-susceptible mice.
Copyright © 2019 Elsevier Inc. All rights reserved.
Comment on
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Microbiotas from Humans with Inflammatory Bowel Disease Alter the Balance of Gut Th17 and RORγt+ Regulatory T Cells and Exacerbate Colitis in Mice.Immunity. 2019 Jan 15;50(1):212-224.e4. doi: 10.1016/j.immuni.2018.12.015. Immunity. 2019. PMID: 30650377 Free PMC article.
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