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Review
. 2019;91(2):118-127.
doi: 10.1159/000495698. Epub 2019 Jan 16.

Diabetes and Metabolic Syndrome in Survivors of Childhood Cancer

Danielle Novetsky Friedman  1 , Emily S Tonorezos  2 , Paul Cohen  2   3
Affiliations
Review

Diabetes and Metabolic Syndrome in Survivors of Childhood Cancer

Danielle Novetsky Friedman et al. Horm Res Paediatr. 2019.

Abstract

Endocrine complications, including diabetes and metabolic syndrome, are highly prevalent in childhood cancer survivors. These metabolic derangements may contribute to survivors' risk of excess cardiovascular morbidity and premature mortality. This review summarizes existing knowledge on risk of diabetes and metabolic syndrome among childhood cancer survivors, focusing specifically on known risk factors, potential mechanisms, and screening recommendations. Early diagnosis via standardized risk-based screening can improve long-term outcomes in this population. Additional work is needed to elucidate the mechanisms underlying these metabolic complications and to inform the design of risk-reducing interventions and optimize long-term cardiometabolic health among survivors of childhood cancer.

Keywords: Body composition; Bone marrow transplantation; Diabetes mellitus; Endocrine dysfunction; Insulin resistance; Long-term follow-up; Metabolic disease; Metabolic syndrome; Oncology.

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Conflict of interest statement

Conflicts of Interest: The authors declare no conflict of interest.

Figures

Figure 1.
Figure 1.
Pathophysiology of metabolic syndrome Abbreviations: TG=triglycerides; HDL=high density lipoprotein, CRP=C-reactive protein; GH=growth hormone; IL-6=interleukin-6; TNF-α= tumor necrosis factor alpha
See this image and copyright information in PMC

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