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Multicenter Study
. 2019 Jan 22;8(2):e010640.
doi: 10.1161/JAHA.118.010640.

Trends in Statin Use Among US Adults With Chronic Kidney Disease, 1999-2014

Matthew T Mefford  1 , Robert S Rosenson  2 , Luqin Deng  1 , Rikki M Tanner  1 , Vera Bittner  1 , Monika M Safford  3 , Blai Coll  4 , Katherine E Mues  4 , Keri L Monda  4 , Paul Muntner  1
Affiliations
Multicenter Study

Trends in Statin Use Among US Adults With Chronic Kidney Disease, 1999-2014

Matthew T Mefford et al. J Am Heart Assoc. .

Abstract

Background The 2013 American College of Cardiology/American Heart Association cholesterol guidelines recognize cardiovascular disease and diabetes mellitus but not chronic kidney disease ( CKD ) as high-risk conditions warranting statin therapy. Statin use may be lower for adults with CKD compared with adults with conditions that have guideline indications for statin use. Methods and Results We analyzed data from the National Health and Nutrition Examination Surveys from 1999-2002 through 2011-2014 to determine trends in the percentage of US adults ≥20 years of age with and without CKD taking statins. CKD was defined by an estimated glomerular filtration rate <60 mL/min per 1.73m2 or albumin-to-creatinine ratio ≥30 mg/g. Statin use was identified through a medication inventory. Between 1999-2002 and 2011-2014, the percentage of adults taking statins increased from 17.6% to 35.7% among those with CKD and from 6.8% to 14.7% among those without CKD . After multivariable adjustment, adults with CKD were not more likely to be taking statins compared with those without CKD (prevalence ratio, 1.01; 95% CI] 0.96-1.08). Among adults without a history of cardiovascular disease, those with CKD but not diabetes mellitus were less likely to be taking statins compared with those with diabetes mellitus but not CKD (prevalence ratio, 0.54; 95% CI , 0.44-0.66). Among adults with a history of cardiovascular disease, there was no difference in statin use between those with CKD but not diabetes mellitus versus those with diabetes mellitus but not CKD (prevalence ratio, 0.95; 95% CI , 0.79-1.15). Conclusions CKD does not appear to be a major stimulus for statin use among US adults.

Keywords: chronic kidney disease; statin; trends.

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Figures

Figure 1
Figure 1
Percentage of statin use among US adults ≥20 years old in CVD risk groups, NHANES 1999–2014. ASCVD indicates atherosclerotic cardiovascular disease; CKD, chronic kidney disease; CVD, cardiovascular disease; NHANES, National Health and Nutrition Examination Survey.
Figure 2
Figure 2
Percentage of statin use among US adults ≥20 years old with CKD and no diabetes vs diabetes and no CKD, by history of CVD, NHANES 1999–2014. CKD indicates chronic kidney disease; CVD, cardiovascular disease; NHANES, National Health and Nutrition Examination Survey.
See this image and copyright information in PMC

References

    1. Segura J, Campo C, Gil P, Roldan C, Vigil L, Rodicio JL, Ruilope LM. Development of chronic kidney disease and cardiovascular prognosis in essential hypertensive patients. J Am Soc Nephrol. 2004;15:1616–1622. - PubMed
    1. Foley RN, Murray AM, Li S, Herzog CA, McBean AM, Eggers PW, Collins AJ. Chronic kidney disease and the risk for cardiovascular disease, renal replacement, and death in the United States Medicare population, 1998 to 1999. J Am Soc Nephrol. 2005;16:489–495. - PubMed
    1. Fox CS, Matsushita K, Woodward M, Bilo HJ, Chalmers J, Heerspink HJ, Lee BJ, Perkins RM, Rossing P, Sairenchi T, Tonelli M, Vassalotti JA, Yamagishi K, Coresh J, de Jong PE, Wen CP, Nelson RG; Chronic Kidney Disease Prognosis Consortium . Associations of kidney disease measures with mortality and end‐stage renal disease in individuals with and without diabetes: a meta‐analysis. Lancet. 2012;380:1662–1673. - PMC - PubMed
    1. Matsushita K, Coresh J, Sang Y, Chalmers J, Fox C, Guallar E, Jafar T, Jassal SK, Landman GW, Muntner P, Roderick P, Sairenchi T, Schottker B, Shankar A, Shlipak M, Tonelli M, Townend J, van Zuilen A, Yamagishi K, Yamashita K, Gansevoort R, Sarnak M, Warnock DG, Woodward M, Arnlov J; CKD Prognosis Consortium . Estimated glomerular filtration rate and albuminuria for prediction of cardiovascular outcomes: a collaborative meta‐analysis of individual participant data. Lancet Diabetes Endocrinol. 2015;3:514–525. - PMC - PubMed
    1. Bansal N, Katz R, Robinson‐Cohen C, Odden MC, Dalrymple L, Shlipak MG, Sarnak MJ, Siscovick DS, Zelnick L, Psaty BM, Kestenbaum B, Correa A, Afkarian M, Young B, de Boer IH. Absolute rates of heart failure, coronary heart disease, and stroke in chronic kidney disease: an analysis of 3 community‐based cohort studies. JAMA Cardiol. 2017;2:314–318. - PMC - PubMed

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