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Review
. 2019 May;62(5):149-154.
doi: 10.3345/kjp.2018.07276. Epub 2019 Jan 14.

A perspective on partially hydrolyzed protein infant formula in nonexclusively breastfed infants

Yvan Vandenplas  1 , Zakiudin Munasir  2 , Badriul Hegar  2 , Dewi Kumarawati  3 , Ahmad Suryawan  4 , Muzal Kadim  2 , Julistio Tb Djais  5 , Ray Wagiu Basrowi  6 , Deni Krisnamurti  6
Affiliations
Review

A perspective on partially hydrolyzed protein infant formula in nonexclusively breastfed infants

Yvan Vandenplas et al. Korean J Pediatr. 2019 May.

Abstract

The World Health Organization recommends that infants should be exclusively breastfed for the first 6 months of life to provide optimal nutrition in this critical period of life. After this, infants should receive nutritionally adequate and safe complementary foods while breastfeeding continues for up to 2 years of age or beyond. For nonbreastfed infants, infant formula is an available option to provide the nutrition needed. Infant formula is usually prepared from industrially modified cow's milk and processed to adjust for the nutritional needs of infants. However, cow's milk is one of the most common causes of food allergy, affecting 2%-5% of all formula-fed infants during their first year of life. One strategy to prevent cow's milk allergy in nonbreastfed infants is the use of partially hydrolyzed formula (pHF) in high-risk infants, which are infants born in families with atopic disease. However, based on an epidemiological study, approximately half of the infants who develop allergy are not part of the at-risk group. This is because the non-at-risk group is significantly larger than the at-risk group and the non-at-risk infants have approximately 15% risk of developing allergies. This study aimed to evaluate the effects of partially hydrolyzed whey formula (pHF-W) in nonbreastfed infants and determine whether pHF-W can prevent atopic disease in high-risk infants and can be used as routine starter formula regardless of the allergy risk status.

Keywords: Breastfeeding; Cow’s milk protein allergy; Formula feeding; Hydrolysate; Infant feeding; Partial hydrolysate.

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Conflict of interest statement

YV has participated as a clinical investigator, advisory board member, consultant, and/or speaker for Abbott Nutrition, Astel Medica, Danone, Nestle Health Science, Nestle Nutrition Institute, Nutricia, Mead Johnson Nutrition, United Pharmaceuticals, and Wyeth. RWB and DK are employees of Nestle Nutrition Institute Indonesia. None of the other authors have conflict of interest.

Figures

Fig. 1.
Fig. 1.
Primary allergy prevention in children. Adapted from Indonesia Pediatric Society Guideline, 2015 [17].
Fig. 2.
Fig. 2.
Proposed dietary options according to breastfeeding and/or family history of atopic disease. BF, breastfeeding; pHF, partially hydrolyzed formula; eHF, extensively hydrolyzed formula; SIF, standard infant formula. Adapted from Vandenplas Y. Nutrients 2017;9(7). pii: E731 [5].
See this image and copyright information in PMC

References

    1. Martin CR, Ling PR, Blackburn GL. Review of infant feeding: key features of breast milk and infant formula. Nutrients. 2016;8(5) doi: 10.3390/nu8050279. pii: E279. - DOI - PMC - PubMed
    1. World Health Organization . Geneva (Switzerland): World Health Organization; 2002. Infant and young child nutrition [Internet] [cited 2018 May 5]. Available from: https://www.who.int/nutrition/topics/WHA55.25_iycn_en.pdf.
    1. ESPGHAN Committee on Nutrition. Agostoni C, Braegger C, Decsi T, Kolacek S, Koletzko B, et al. Breast-feeding: a commentary by the ESPGHAN Committee on Nutrition. J Pediatr Gastroenterol Nutr. 2009;49:112–25. - PubMed
    1. World Health Organization . Infant and young child feeding: model chapter for textbooks for medical students and allied health professionals. Geneva (Switzerland): World Health Organization; 2009. - PubMed
    1. Vandenplas Y. Prevention and management of cow's milk allergy in non-exclusively breastfed infants. Nutrients 2. 2017;9(7) doi: 10.3390/nu9070731. pii: E731. - DOI - PMC - PubMed

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