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Review
. 2018 Dec 16:2018:8693137.
doi: 10.1155/2018/8693137. eCollection 2018.

Secretomes from Mesenchymal Stem Cells against Acute Kidney Injury: Possible Heterogeneity

Kenji Tsuji  1 , Shinji Kitamura  1 , Jun Wada  1
Affiliations
Review

Secretomes from Mesenchymal Stem Cells against Acute Kidney Injury: Possible Heterogeneity

Kenji Tsuji et al. Stem Cells Int. .

Abstract

A kidney has the ability to regenerate itself after a variety of renal injuries. Mesenchymal stem cells (MSCs) have been shown to ameliorate tissue damages during renal injuries and diseases. The regenerations induced by MSCs are primarily mediated by the paracrine release of soluble factors and extracellular vesicles, including exosomes and microvesicles. Extracellular vesicles contain proteins, microRNAs, and mRNAs that are transferred into recipient cells to induce several repair signaling pathways. Over the past few decades, many studies identified trophic factors from MSCs, which attenuate renal injury in a variety of animal acute kidney injury models, including renal ischemia-reperfusion injury and drug-induced renal injury, using microarray and proteomic analysis. Nevertheless, these studies have revealed the heterogeneity of trophic factors from MSCs that depend on the cell origins and different stimuli including hypoxia, inflammatory stimuli, and aging. In this review article, we summarize the secretomes and regenerative mechanisms induced by MSCs and highlight the possible heterogeneity of trophic factors from different types of MSC and different circumstances for renal regeneration.

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Figures

Figure 1
Figure 1
Schema of trophic mechanisms via secretomes from mesenchymal stem cells.
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References

    1. Silver S. A., Harel Z., McArthur E., et al. Causes of death after a hospitalization with AKI. Journal of the American Society of Nephrology. 2018;29(3):1001–1010. doi: 10.1681/ASN.2017080882. - DOI - PMC - PubMed
    1. Hsu R. K., Hsu C. Y. The role of acute kidney injury in chronic kidney disease. Seminars in Nephrology. 2016;36(4):283–292. doi: 10.1016/j.semnephrol.2016.05.005. - DOI - PMC - PubMed
    1. Forni L. G., Darmon M., Ostermann M., et al. Renal recovery after acute kidney injury. Intensive Care Medicine. 2017;43(6):855–866. doi: 10.1007/s00134-017-4809-x. - DOI - PMC - PubMed
    1. Pittenger M. F., Mackay A. M., Beck S. C., et al. Multilineage potential of adult human mesenchymal stem cells. Science. 1999;284(5411):143–147. doi: 10.1126/science.284.5411.143. - DOI - PubMed
    1. Broekema M., Harmsen M. C., Koerts J. A., et al. Determinants of tubular bone marrow-derived cell engraftment after renal ischemia/reperfusion in rats. Kidney International. 2005;68(6):2572–2581. doi: 10.1111/j.1523-1755.2005.00728.x. - DOI - PubMed

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