Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Jan;17(1):349-353.
doi: 10.3892/etm.2018.6893. Epub 2018 Oct 24.

Arterial blood gas and acid-base balance in patients with pregnancy-induced hypertension syndrome

Yali Cao  1 , Meichun Wang  2 , Yuchao Yuan  3 , Cong Li  4 , Qinglin Bai  5 , Min Li  1
Affiliations

Arterial blood gas and acid-base balance in patients with pregnancy-induced hypertension syndrome

Yali Cao et al. Exp Ther Med. 2019 Jan.

Abstract

This study aimed to investigate the expression of arterial blood gas and acid-base balance in patients with pregnancy-induced hypertension syndrome and their influence on newborns. A total of 348 patients with pregnancy-induced hypertension syndrome (research group) admitted and treated in the First People's Hospital of Jining from March 2013 to March 2016 were retrospectively analyzed, and another 156 cases of healthy pregnant women who were physically examined were selected as the control group. Blood gas analysis was performed on pregnant women, and pH value, partial pressure of oxygen (PO2), partial pressure of carbon dioxide (PCO2), bicarbonate radical (HCO3-) and base excess (BE) were included as test indexes. Apgar score was made for newborns for neonatal asphyxia. The evaluation was performed at 1, 5, and 10 min after birth to analyze the correlation between the maternal arterial blood pH and the neonatal Apgar score. The pH value, and PO2 and HCO3- levels in the research group were lower than those in the control group (p<0.05). PCO2 and BE levels in the research group were higher than those in the control group (p<0.05). The incidence of neonatal mild asphyxia (Apgar score, 4-6 points) and neonatal severe asphyxia (Apgar score, <4 points) in the research group were higher than that in the control group (p<0.05). The Apgar score of newborns was positively correlated with the pH value of the arterial blood of pregnant women. Blood gas analysis in patients with pregnancy-induced hypertension syndrome is useful to a certain extent to evaluate the condition of the patient. The combination of the pH value of the patient and the Apgar score of the newborns may help improve the judgement rate of neonatal asphyxia so as to improve the quality of childbirth by early monitoring and intervention of the newborns.

Keywords: Apgar score; acid-base balance; blood gas analysis; neonatal asphyxia; pregnancy-induced hypertension syndrome.

PubMed Disclaimer

References

    1. Lo JO, Mission JF, Caughey AB. Hypertensive disease of pregnancy and maternal mortality. Curr Opin Obstet Gynecol. 2013;25:124–132. doi: 10.1097/GCO.0b013e32835e0ef5. - DOI - PubMed
    1. van Middendorp D, ten Asbroek A, Bio FY, Edusei A, Meijjer L, Newton S, Agyemang C. Rural and urban differences in blood pressure and pregnancy-induced hypertension among pregnant women in Ghana. Global Health. 2013;9:59. doi: 10.1186/1744-8603-9-59. - DOI - PMC - PubMed
    1. Dunietz GL, Strutz KL, Holzman C, Tian Y, Todem D, Bullen BL, Catov JM. Moderately elevated blood pressure during pregnancy and odds of hypertension later in life: The POUCHmoms longitudinal study. BJOG. 2017;124:1606–1613. doi: 10.1111/1471-0528.14556. - DOI - PMC - PubMed
    1. Veerbeek JH, Hermes W, Breimer AY, van Rijn BB, Koenen SV, Mol BW, Franx A, de Groot CJ, Koster MP. Cardiovascular disease risk factors after early-onset preeclampsia, late-onset preeclampsia, and pregnancy-induced hypertension. Hypertension. 2015;65:600–606. doi: 10.1161/HYPERTENSIONAHA.114.04850. - DOI - PubMed
    1. Cnattingius S, Norman M, Granath F, Petersson G, Stephansson O, Frisell T. Apgar score components at 5 minutes: Risks and prediction of neonatal mortality. Paediatr Perinat Epidemiol. 2017;31:328–337. doi: 10.1111/ppe.12360. - DOI - PubMed