Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2018 Dec;7(6):484-486.
doi: 10.21037/hbsn.2018.10.03.

NGM282: a step forward in the nonalcoholic steatohepatitis treatment landscape?

Affiliations
Editorial

NGM282: a step forward in the nonalcoholic steatohepatitis treatment landscape?

Luca Valenti et al. Hepatobiliary Surg Nutr. 2018 Dec.
No abstract available

PubMed Disclaimer

Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Hypothetical mechanisms linking the FXR-FGF19-FGFR4-β-Klotho axis with hepatic fat accumulation and liver damage, and therapeutic approaches to modulate this pathway.

Comment on

Similar articles

Cited by

References

    1. Younossi ZM, Koenig AB, Abdelatif D, et al. Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes. Hepatology 2016;64:73-84. 10.1002/hep.28431 - DOI - PubMed
    1. Estes C, Anstee QM, Teresa Arias-Loste M, et al. Modeling NAFLD Disease Burden in China, France, Germany, Italy, Japan, Spain, United Kingdom, and United States for the period 2016-2030. J Hepatol 2018;69:896-904. 10.1016/j.jhep.2018.05.036 - DOI - PubMed
    1. Nobili V, Svegliati-Baroni G, Alisi A, et al. A 360-Degree Overview Of Paediatric Nafld: Recent Insights. J Hepatol 2013;58:1218-29. 10.1016/j.jhep.2012.12.003 - DOI - PubMed
    1. Tilg H, Moschen AR. Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesis. Hepatology 2010;52:1836-46. 10.1002/hep.24001 - DOI - PubMed
    1. Dongiovanni P, Stender S, Pietrelli A, et al. Causal relationship of hepatic fat with liver damage and insulin resistance in nonalcoholic fatty liver. J Intern Med 2018;283:356-70. 10.1111/joim.12719 - DOI - PMC - PubMed