Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Nov-Dec;33(6):603-607.
doi: 10.21470/1678-9741-2018-0174.

Risk Factors for Mortality in Children with Congenital Heart Disease Delivered at a Brazilian Tertiary Center

Luciane Alves Rocha  1 , Sthefane Catib Froio  1 , Célia Camelo Silva  2 , Simone de Araujo Negreiros Figueira  3 , José Cícero Stocco Guilhen  4 , Ruth Guinsburg  3 , Edward Araujo Júnior  1
Affiliations

Risk Factors for Mortality in Children with Congenital Heart Disease Delivered at a Brazilian Tertiary Center

Luciane Alves Rocha et al. Braz J Cardiovasc Surg. 2018 Nov-Dec.

Abstract

Objective: This study aims to investigate the incidence of postnatal diagnosis of congenital heart disease (CHD) and the predictive factors for hospital mortality.

Methods: This retrospective cohort study was conducted at a Brazilian tertiary center, and data were collected from medical records with inclusion criteria defined as any newborn with CHD diagnosed in the postnatal period delivered between 2015 and 2017. Univariate and multivariate analyses were performed to determine the potential risk factors for mortality.

Results: During the 3-year period, 119 (5.3%) children of the 2215 children delivered at our institution were diagnosed with CHD. We considered birth weight (P=0.005), 1st min Apgar score (P=0.001), and CHD complexity (P=0.013) as independent risk factors for in-hospital mortality. The most common CHD was ventricular septal defect. Indeed, 60.5% cases were considered as "complex" or "significant" CHDs. Heart surgeries were performed on 38.9% children, 15 of whom had "complex" or "significant" CHD. A mortality rate of 42% was observed in this cohort, with 28% occurring within the initial 24 h after delivery and 38% occurring in patients admitted for heart surgery.

Conclusion: The postnatal incidence of CHD at our service was 5.3%. Low 1st min Apgar score, low birth weight, and CHD complexity were the independent factors that affected the hospital outcome.

PubMed Disclaimer

Conflict of interest statement

No conflict of interest

Figures

Fig. 1
Fig. 1
The frequency of surgical cases and mortality based on the study RACHS (n=46).
See this image and copyright information in PMC

References

    1. Carvalho JS, Mavrides E, Shinebourne EA, Campbell S, Thilaganathan B. Improving the effectiveness of routine prenatal screening for major congenital heart defects. Heart. 2002;88(4):387–391. - PMC - PubMed
    1. Yu Z, Xi Y, Ding W, Han S, Cao L, Zhu C, et al. Congenital heart disease in a Chinese hospital: pre- and postnatal detection, incidence, clinical characteristics and outcomes. Pediatr Int. 2011;53(6):1059–1065. - PubMed
    1. Ozbarlas N, Erdem S, Küçükosmanoglu O, Seydaoglu G, Demir C, Evrüke C, et al. Prevalence and distribution of structural heart diseases in high and low risk pregnancies. Anadolu Kardiyol Derg. 2011;11(2):125–130. - PubMed
    1. Lee JE, Jung KL, Kim SE, Nam SH, Choi SJ, Oh SY, et al. Prenatal diagnosis of congenital heart disease: trends in pregnancy termination rate, and perinatal and 1-year infant mortalities in Korea between 1994 and 2005. J Obstet Gynaecol Res. 2010;36(3):474–478. - PubMed
    1. Friedberg MK, Silverman NH, Moon-Grady AJ, Tong E, Nourse J, Sorenson B, et al. Prenatal detection of congenital heart disease. J Pediatr. 2009;155(1):26–31. - PubMed

LinkOut - more resources