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. 2019 Jan;98(3):e14062.
doi: 10.1097/MD.0000000000014062.

Autologous platelet-rich plasma infusion improves clinical pregnancy rate in frozen embryo transfer cycles for women with thin endometrium

Yajie Chang  1 , Jingjie Li, Li-Na Wei, Jiahui Pang, Jianhui Chen, Xiaoyan Liang
Affiliations

Autologous platelet-rich plasma infusion improves clinical pregnancy rate in frozen embryo transfer cycles for women with thin endometrium

Yajie Chang et al. Medicine (Baltimore). 2019 Jan.

Abstract

Background: Adequate thickness of the endometrium has been well recognized as a critical factor for embryo implantation. This was a prospective cohort study to investigate the benefits of platelet-rich plasma (PRP) for women with thin endometrium who received frozen embryo transfer (FET) program in a larger number of patients and explore the underlying mechanism.

Methods: In this study, we investigated the effects of PRP in women with thin endometrium in FET program. 64 patients with thin endometrium (<7 mm) were recruited. PRP intrauterine infusion was given in PRP group during hormone replacement therapy (HRT) cycle in FET cycles.

Results: After PRP infusion, the endometrium thickness in PRP group was 7.65 ± 0.22 mm, which was significantly thicker than that in control group (6.52 ± 0.31 mm) (P <.05). Furthermore, PRP group had lower cycle cancellation rate when compared to control group (19.05% vs. 41.18%, P <.01). The implantation rate and clinical pregnancy rate in PRP group were significantly higher than those in control group (27.94% vs 11.67%, P <.05; 44.12% vs 20%, P <.05, respectively). PRP blood contained 4 folds higher platelets and significantly greater amounts of growth factors including platelet-derived growth factor (PDGF)-AB, PDGF-BB, and transforming growth factor (TGF)-β than peripheral blood (P <.01).

Conclusions: PRP plays a positive role in promoting endometrium proliferation, improving embryo implantation rate and clinical pregnancy rate for women with thin endometrium in FET cycles.

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Conflict of interest statement

The authors declare no conflicts of interest that could appear to have influenced the submitted work.

Figures

Figure 1
Figure 1
The concentrations of PDGF-AB, PDGF-BB and TGF-β in PRP and whole blood. The data are expressed as the mean ± SD. PDGF = platelet-derived growth factor, PRP = platelet-rich plasma, TGF = transforming growth factor.
See this image and copyright information in PMC

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