Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2019 Jan 17;15(1):e1007854.
doi: 10.1371/journal.pgen.1007854. eCollection 2019 Jan.

It starts at the ends: The zebrafish meiotic bouquet is where it all begins

Kellee R Siegfried  1
Affiliations
Comment

It starts at the ends: The zebrafish meiotic bouquet is where it all begins

Kellee R Siegfried. PLoS Genet. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The author declares that no competing interests exist.

Figures

Fig 1
Fig 1. Meiotic DSBs, homologous chromosome pairing, and synapsis are initiated near the chromosome ends in the meiotic bouquet.
In the leptotene stage of meiotic prophase, telomeres attach to the nuclear envelope and by early zygotene, move to one region of the nuclear envelope to form the bouquet structure. In the bouquet, DSBs, homologous chromosome pairing, and synapsis between homologs is initiated near the chromosome ends. Telomeres can associate with each other nonspecifically—telomeres from nonhomologous chromosomes are often juxtaposed (nonhomologous chromosomes are represented by different colors). Pairing between homologous chromosome is then seen and initiates close to the telomeres. Synapsis, as visualized by formation of the synaptonemal complex (green lateral element + blue central region), begins in paired regions near telomeres. As pairing extends along the length of the chromosome, synapsis ensues. DSB, double-strand break.
See this image and copyright information in PMC

Comment on

Similar articles

See all similar articles

Cited by

References

    1. Bolcun-Filas E, Handel MA. Meiosis: the chromosomal foundation of reproduction. Biol Reprod. 2018;99: 112–126. 10.1093/biolre/ioy021 - DOI - PubMed
    1. Zeng X, Li K, Yuan R, Gao H, Luo J, Liu F, et al. Nuclear Envelope-Associated Chromosome Dynamics during Meiotic Prophase I. Front cell Dev Biol. 2017;5: 121 10.3389/fcell.2017.00121 - DOI - PMC - PubMed
    1. Gao J, Colaiácovo MP. Zipping and Unzipping: Protein Modifications Regulating Synaptonemal Complex Dynamics. Trends Genet. 2018;34: 232–245. 10.1016/j.tig.2017.12.001 - DOI - PMC - PubMed
    1. Knaut H, Werz C, Geisler R, Nüsslein-Volhard C, Tübingen 2000 Screen Consortium. A zebrafish homologue of the chemokine receptor Cxcr4 is a germ-cell guidance receptor. Nature. 2003;421: 279–282. 10.1038/nature01338 - DOI - PubMed
    1. Doitsidou M, Reichman-Fried M, Stebler J, Köprunner M, Dörries J, Meyer D, et al. Guidance of primordial germ cell migration by the chemokine SDF-1. Cell. 2002;111: 647–59. Available: http://www.ncbi.nlm.nih.gov/pubmed/12464177 - PubMed