Review
doi: 10.1016/j.neuron.2018.12.027.
Crosstalk of Local Translation and Mitochondria: Powering Plasticity in Axons and Dendrites
Affiliations
- PMID: 30653934
- DOI: 10.1016/j.neuron.2018.12.027
Item in Clipboard
Review
Crosstalk of Local Translation and Mitochondria: Powering Plasticity in Axons and Dendrites
Neuron.
.
Free article
Abstract
Two papers in Cell uncover reciprocal crosstalk of local translation and mitochondria in neurons. Rangaraju et al. (2019) observe tethered compartments of stable mitochondria in dendrites that provide a local energy supply for mRNA translation at synapses. Cioni et al. (2019) report a novel association of axonal RNA granules with Rab7a-late endosomes that provides a platform for local translation supporting mitochondria.
Copyright © 2018 Elsevier Inc. All rights reserved.
Similar articles
-
Spatially Stable Mitochondrial Compartments Fuel Local Translation during Plasticity.Cell. 2019 Jan 10;176(1-2):73-84.e15. doi: 10.1016/j.cell.2018.12.013. Epub 2019 Jan 3. Cell. 2019. PMID: 30612742
-
Late Endosomes Act as mRNA Translation Platforms and Sustain Mitochondria in Axons.Cell. 2019 Jan 10;176(1-2):56-72.e15. doi: 10.1016/j.cell.2018.11.030. Epub 2019 Jan 3. Cell. 2019. PMID: 30612743 Free PMC article.
-
Localization and translation of mRNA in dendrites and axons.Nat Rev Neurosci. 2001 Dec;2(12):889-98. doi: 10.1038/35104069. Nat Rev Neurosci. 2001. PMID: 11733796 Review. No abstract available.
-
A Functional Dissection of the mRNA and Locally Synthesized Protein Population in Neuronal Dendrites and Axons.Annu Rev Genet. 2021 Nov 23;55:183-207. doi: 10.1146/annurev-genet-030321-054851. Epub 2021 Aug 30. Annu Rev Genet. 2021. PMID: 34460296
-
mRNP assembly, axonal transport, and local translation in neurodegenerative diseases.Brain Res. 2018 Aug 15;1693(Pt A):75-91. doi: 10.1016/j.brainres.2018.02.018. Epub 2018 Feb 17. Brain Res. 2018. PMID: 29462608 Free PMC article. Review.
Cited by
-
FUS-mediated HypEVs: Neuroprotective effects against ischemic stroke.Bioact Mater. 2023 Jul 16;29:196-213. doi: 10.1016/j.bioactmat.2023.07.009. eCollection 2023 Nov. Bioact Mater. 2023. PMID: 37621770 Free PMC article.
-
Spatiotemporal Insights Into RNA-Organelle Interactions in Neurons.Front Cell Dev Biol. 2021 Jun 10;9:663367. doi: 10.3389/fcell.2021.663367. eCollection 2021. Front Cell Dev Biol. 2021. PMID: 34178987 Free PMC article. Review.
-
The Role of PGC-1α-Mediated Mitochondrial Biogenesis in Neurons.Neurochem Res. 2023 Sep;48(9):2595-2606. doi: 10.1007/s11064-023-03934-8. Epub 2023 Apr 25. Neurochem Res. 2023. PMID: 37097395 Review.
-
The multi PAM2 protein Upa2 functions as novel core component of endosomal mRNA transport.EMBO Rep. 2019 Sep;20(9):e47381. doi: 10.15252/embr.201847381. Epub 2019 Jul 24. EMBO Rep. 2019. PMID: 31338952 Free PMC article.
-
Polar localization and local translation of RHO-RELATED PROTEIN FROM PLANTS2 mRNAs promote root hair growth in Arabidopsis.Plant Cell. 2024 Dec 23;37(1):koae333. doi: 10.1093/plcell/koae333. Plant Cell. 2024. PMID: 39692591
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
