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. 2019 May;143(5):1928-1930.e3.
doi: 10.1016/j.jaci.2018.12.1002. Epub 2019 Jan 14.

Prevalence of eosinophilic colitis and the diagnoses associated with colonic eosinophilia

Lauren A DiTommaso  1 , Chen E Rosenberg  1 , Michael D Eby  1 , Amy Tasco  1 , Margaret H Collins  2 , John L Lyles  3 , Philip E Putnam  3 , Vincent A Mukkada  3 , Marc E Rothenberg  4
Affiliations

Prevalence of eosinophilic colitis and the diagnoses associated with colonic eosinophilia

Lauren A DiTommaso et al. J Allergy Clin Immunol. 2019 May.

Abstract

Pediatric eosinophilic colitis (EC) is a rare disease with a prevalence of ~1/63,000 individuals, and at our tertiary care pediatric medical center, only 2% of patients with the ICD-9/10 code for EC likely have the disease.

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Conflict of interest statement

Conflicts of Interest

PEP has received payment for lectures from Abbott Nutrition. VAM reports grants and personal fees from Shire. MER is a consultant for PulmOne, Spoon Guru, Celgene, Shire, AstraZeneca, GlaxoSmithKline, Allakos, Adare, Regeneron, and Novartis; has an equity interest in PulmOne, Spoon Guru, Celgene, and Immune Pharmaceuticals; receives royalties from reslizumab (Teva Pharmaceuticals) and UpToDate; and is an inventor of patents owned by Cincinnati Children’s Hospital Medical Center. The rest of the authors declare no relevant conflicts of interest.

Figures

Figure 1.
Figure 1.. Methods Flow Chart.
Retrospective analyses to 1) identify cases of colonic eosinophilia; 2) determine the diseases associated with colonic eosinophilia; and 3) estimate the prevalence of EC were performed using two independent approaches by searching the pathology and electronic medical record (Epic) databases as outlined by the flow chart. The dotted line indicates the point at which an in-depth chart review was conducted.
Figure 2.
Figure 2.. Disease Categories Associated with Colonic Eosinophilia in Patients with Probable EC or Without EC.
Percentage (%) of patients (N = 172) in each disease category (probable EC or without EC) with the number of patients in each disease category labeled above the corresponding bar. IBD, inflammatory bowel disease.
See this image and copyright information in PMC

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