Review

. 2019 Jan 16;24(2):314.

doi: 10.3390/molecules24020314.

Chiral Derivatives of Xanthones with Antimicrobial Activity

Joana Araújo¹, Carla Fernandes^{2

3}, Madalena Pinto^{4

5}, Maria Elizabeth Tiritan^{6

7

8}

Affiliations

¹ Laboratory of Organic and Pharmaceutical Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal. up201703236@ff.up.pt.
² Laboratory of Organic and Pharmaceutical Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal. cfernandes@ff.up.pt.
³ Interdisciplinary Center of Marine and Environmental Research (CIIMAR), University of Porto, Edificio do Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos s/n, 4050-208 Matosinhos, Portugal. cfernandes@ff.up.pt.
⁴ Laboratory of Organic and Pharmaceutical Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal. madalena@ff.up.pt.
⁵ Interdisciplinary Center of Marine and Environmental Research (CIIMAR), University of Porto, Edificio do Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos s/n, 4050-208 Matosinhos, Portugal. madalena@ff.up.pt.
⁶ Laboratory of Organic and Pharmaceutical Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal. elizabeth.tiritan@iucs.cespu.pt.
⁷ Interdisciplinary Center of Marine and Environmental Research (CIIMAR), University of Porto, Edificio do Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos s/n, 4050-208 Matosinhos, Portugal. elizabeth.tiritan@iucs.cespu.pt.
⁸ Institute of Research and Advanced Training in Health Sciences and Technologies, Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Rua Central de Gandra, 1317, 4585-116 Gandra PRD, Portugal. elizabeth.tiritan@iucs.cespu.pt.

PMID: 30654546
PMCID: PMC6359477
DOI: 10.3390/molecules24020314

Review

Chiral Derivatives of Xanthones with Antimicrobial Activity

Joana Araújo et al. Molecules. 2019.

. 2019 Jan 16;24(2):314.

doi: 10.3390/molecules24020314.

Authors

Joana Araújo¹, Carla Fernandes^{2

3}, Madalena Pinto^{4

5}, Maria Elizabeth Tiritan^{6

7

8}

Affiliations

¹ Laboratory of Organic and Pharmaceutical Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal. up201703236@ff.up.pt.
² Laboratory of Organic and Pharmaceutical Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal. cfernandes@ff.up.pt.
³ Interdisciplinary Center of Marine and Environmental Research (CIIMAR), University of Porto, Edificio do Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos s/n, 4050-208 Matosinhos, Portugal. cfernandes@ff.up.pt.
⁴ Laboratory of Organic and Pharmaceutical Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal. madalena@ff.up.pt.
⁵ Interdisciplinary Center of Marine and Environmental Research (CIIMAR), University of Porto, Edificio do Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos s/n, 4050-208 Matosinhos, Portugal. madalena@ff.up.pt.
⁶ Laboratory of Organic and Pharmaceutical Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal. elizabeth.tiritan@iucs.cespu.pt.
⁷ Interdisciplinary Center of Marine and Environmental Research (CIIMAR), University of Porto, Edificio do Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos s/n, 4050-208 Matosinhos, Portugal. elizabeth.tiritan@iucs.cespu.pt.
⁸ Institute of Research and Advanced Training in Health Sciences and Technologies, Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Rua Central de Gandra, 1317, 4585-116 Gandra PRD, Portugal. elizabeth.tiritan@iucs.cespu.pt.

PMID: 30654546
PMCID: PMC6359477
DOI: 10.3390/molecules24020314

Abstract

According to the World Health Organization, the exacerbated use of antibiotics worldwide is increasing multi-resistant infections, especially in the last decade. Xanthones are a class of compounds receiving great interest in drug discovery and development that can be found as natural products or obtained by synthesis. Many derivatives of xanthones are chiral and associated with relevant biological activities, including antimicrobial. The aim of this review is to compile information about chiral derivatives of xanthones from natural sources and their synthesized examples with antimicrobial activity.

Keywords: antimicrobial; caged xanthones; chiral derivatives of xanthones; chirality; xanthones.

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Conflict of interest statement

The authors declare no conflict of interest.

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Chiral Derivatives of Xanthones with Antimicrobial Activity

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Chiral Derivatives of Xanthones with Antimicrobial Activity

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