Published Erratum
doi: 10.1016/j.redox.2019.101101.
Epub 2019 Jan 14.
Corrigendum to "Polydatin prevents fructose-induced liver inflammation and lipid deposition through increasing miR-200a to regulate Keap1/Nrf2 pathway" [Redox Biol. 18 (2018) 124-137]
Affiliations
- PMID: 30655077
- PMCID: PMC6435944
- DOI: 10.1016/j.redox.2019.101101
Item in Clipboard
Published Erratum
Corrigendum to "Polydatin prevents fructose-induced liver inflammation and lipid deposition through increasing miR-200a to regulate Keap1/Nrf2 pathway" [Redox Biol. 18 (2018) 124-137]
Redox Biol.
2019 Apr.
No abstract available
Figures
Polydatin alleviates liver inflammation and lipid deposition in fructose-fed rats. Rats were fed 10% fructose drinking water (wt/vl) for 13 weeks and treated with polydtain (7.5, 15, 30 mg/kg) and pioglitazone (4 mg/kg) during the last 7 weeks. (A) qRT-PCR analysis of TXNIP mRNA levels, and (B) Western blot analysis of TXNIP protein levels in rat livers (n = 4 at least). Relative mRNA levels of TXNIP were normalized to β-actin. Relative protein levels of TXNIP were normalized to GAPDH. (C) Representative microphotograph of H&E-stained and oil-red O-stained paraffin-embedded sections of liver tissues were shown (200 and 400 × magnification; bars, 100 µm), respectively. (D) Western blot analysis of NLRP3, ASC, Caspase-1, IL-1β, PPAR-α, CPT-1, SREBP-1 and SCD-1 protein levels in rat livers (n = 4 at least). Relative protein levels of Caspase-1 were normalized to pro-Caspase-1, of IL-1β were normalized to pro-IL-1β, of TXNIP, NLRP3, ASC, PPAR-α, CPT-1, SREBP-1 and SCD-1 were normalized to GAPDH or β-actin, respectively. All data are expressed as mean ± S.E.M. P value was calculated by one-way ANOVA and further post hoc Dunnett testing. #P < 0.05, ##P < 0.01, ###P < 0.001 compared with control-vehicle; *P < 0.05, **P < 0.01, ***P < 0.001 compared with fructose-vehicle. TXNIP, thioredoxin-interacting protein; NLRP3, The NOD-like receptor (NLR) family, pyrin domain containing 3; ASC, apoptosis-associated speck-like protein; IL-1β, interleukin-1β; PPAR-α, peroxisome proliferator activated receptor-α; CPT-1, carnitine palmitoyl transferase-1; SREBP-1, sterol regulatory element binging protein 1; SCD-1, stearoyl-CoA desaturase-1.
Erratum for
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Polydatin prevents fructose-induced liver inflammation and lipid deposition through increasing miR-200a to regulate Keap1/Nrf2 pathway.Redox Biol. 2018 Sep;18:124-137. doi: 10.1016/j.redox.2018.07.002. Epub 2018 Jul 5. Redox Biol. 2018. PMID: 30014902 Free PMC article.
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