Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Jan;17(1):23-30.
doi: 10.3892/ol.2018.9636. Epub 2018 Oct 29.

Effect of modulation of epithelial-mesenchymal transition regulators Snail1 and Snail2 on cancer cell radiosensitivity by targeting of the cell cycle, cell apoptosis and cell migration/invasion

Ganiou Assani  1   2   3 , Yunfeng Zhou  1   2   3
Affiliations
Review

Effect of modulation of epithelial-mesenchymal transition regulators Snail1 and Snail2 on cancer cell radiosensitivity by targeting of the cell cycle, cell apoptosis and cell migration/invasion

Ganiou Assani et al. Oncol Lett. 2019 Jan.

Abstract

Cancer is one of the leading causes of cancer-associated mortality worldwide. Several strategies of treatment, including radiotherapy, have been developed and used to treat this disease. However, post-treatment metastasis and resistance to treatment are two major causes for the limited effectiveness of radiotherapy in cancer patients. Epithelial-mesenchymal transition (EMT) is regulated by SNAIL family transcription factors, including Snail1 and Snail2 (Slug), and serves important roles in progression and cancer resistance to treatment. Snail1 and Slug also have been shown to be implicated in cancer treatment resistance. For resolving the resistance to treatment problems, combining the modulation of gene expression with radiotherapy is a novel strategy to treat patients with cancer. The present review focuses on the effect of Snail1 and Slug on cancer radiosensitivity by targeting cell apoptosis, the cell cycle and cell migration/invasion.

Keywords: Snail1; Snail2; cancer radiosensitivity; cell apoptosis; cell cycle; cell invasion; cell migration.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Schematic diagram of the function domain of Snail1 and Snail2 zinc finger transcription factors.
Figure 2.
Figure 2.
Schematic diagram of the link between Snail1 and Snail2 inhibition, cell apoptosis, the cell cycle, cell migration/invasion and cancer cell radiosensitivity.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F. International Agency for Research on Cancer. GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide. [Dec;Dec;2013 ];IARC CancerBase No.11.Globocan.iarc.fr.
    1. World Health Organization. Health Statistics and Information Systems. Database.who.int/healthinfo/mortality_data/en/ [Nov 6;2014 ];WHO Mortality.
    1. Ghoncheh M, Pournamdar Z, Salehiniya H. Incidence and mortality and epidemiology of breast cancer in the world. Asian Pac J Cancer Prev. 2016;17:43–46. doi: 10.7314/APJCP.2016.17.S3.43. - DOI - PubMed
    1. Clifton K, Gutierrez-Barrera A, Ma J, Bassett R, Jr, Litton J, Kuerer H, Moulder S, Albarracin C, Hortobagyi G, Arun B. Adjuvant versus neoadjuvant chemotherapy in triple-negative breast cancer patients with BRCA mutations. Breast Cancer Res Treat. 2018;170:101–109. doi: 10.1007/s10549-018-4727-9. - DOI - PMC - PubMed
    1. Lui F, Xu K, Yang H, Li Y, Liu J, Wang J, Guan Z. A novel approach to glioma therapy an oncolytic adenovirus with two specific promoters. Oncol Lett. 2018;15:3362–3368. - PMC - PubMed