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. 2019 Jan;17(1):141-148.
doi: 10.3892/ol.2018.9620. Epub 2018 Oct 25.

High expression of density-regulated re-initiation and release factor drives tumourigenesis and affects clinical outcome

Dazhi Wang  1   2   3 , Lanying Wang  2 , Chunling Ren  4 , Pei Zhang  5 , Mengmeng Wang  6 , Shuyu Zhang  2
Affiliations

High expression of density-regulated re-initiation and release factor drives tumourigenesis and affects clinical outcome

Dazhi Wang et al. Oncol Lett. 2019 Jan.

Abstract

Previously, certain experiments have suggested that density-regulated re-initiation and release factor (DENR) could serve important roles in cancer, however, to the best of our knowledge, a comprehensive analysis of DENR and its association with cancer patient survival is lacking. The aim of the current study was to investigate the expression of DENR in multiple tumour types and to evaluate the effects of DENR on survival in malignancies. Sample expression profiles were downloaded from the Gene Expression Omnibus database. Association between DENR expression and clinicopathological features was analysed by Chi-square tests. The effects of DENR on survival were evaluated by Kaplan-Meier analysis. The results of the current study demonstrate that DENR expression was upregulated in nine cancer types. High DENR expression indicated poor prognosis of patients. The results of the present study demonstrated that DENR is highly expressed in multiple tumour types and may be used as a potential prognostic marker and therapeutic target.

Keywords: cancer biomarkers; density-regulated re-initiation and release factor; poor prognosis.

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Figures

Figure 1.
Figure 1.
Expression of DENR in multiple cancer types. These data were extracted from the Gene Expression Omnibus database. DENR was upregulated in breast, gastric, colorectal, renal, lung, liver, pancreatic, tongue and vulvar cancers. **P<0.01, ***P<0.001 vs. normal, by paired or unpaired t-test. DENR, density-regulated re-initiation and release factor.
Figure 2.
Figure 2.
Association of DENR expression with patient prognosis in gastric cancer, hepatocellular carcinoma, lung cancer, kidney cancer and laryngeal cancer. The association was investigated by Kaplan-Meier analysis and log-rank test. Overall survival of (A) patients with gastric cancer (data from GSE15459) and (B) patients with hepatocellular carcinoma (data from GSE14520). (C) Overall survival and (D) recurrence-free survival of patients with lung cancer (data from GSE 30219). (E) Overall survival of patients with kidney cancer (data from TCGA) and (F) recurrence-free survival of patients with laryngeal cancer (data from GSE27020). DENR, density-regulated re-initiation and release factor; GSE, gene set enrichment.
Figure 3.
Figure 3.
GSEA for lung cancer tissues with high DENR expression (data from GSE30219). GSEA revealed that the enriched gene sets were associated with (A) cell cycle, (B) CR_REPAIR (cancer DNA related repair), (C) DNA damage signalling and (D) mRNA splicing. GSEA, gene set enrichment analysis; DENR, density-regulated re-initiation and release factor.
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