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. 2019 Jan;17(1):623-629.
doi: 10.3892/ol.2018.9614. Epub 2018 Oct 24.

Genetic influence of cytokine polymorphisms on the clinical outcome of Japanese gastrointestinal cancer patients in palliative care

Asahi Hishida  1 , Yoshinaga Okugawa  2   3   4 , Yuhki Morimoto  2 , Yumiko Shirai  5 , Kyoko Okamoto  6 , Sachiko Momokita  4 , Aki Ogawa  6 , Koji Tanaka  2   7 , Ryutaro Nishikawa  2 , Yuji Toiyama  7 , Yasuhiro Inoue  7 , Hiroyuki Sakurai  8 , Hisashi Urata  2 , Motoyoshi Tanaka  3 , Donald C McMillan  9 , Chikao Miki  2   7
Affiliations

Genetic influence of cytokine polymorphisms on the clinical outcome of Japanese gastrointestinal cancer patients in palliative care

Asahi Hishida et al. Oncol Lett. 2019 Jan.

Abstract

Gastrointestinal cancer is one of the most common causes of mortality globally. The present study examined the influence of cytokine genetic polymorphisms [interleukin (IL)-1B C-31T, IL-1RN VNTR, IL-6 C-634G, IL-8 T-251A, IL-10 T-819C and IL-10 A-1082G] on clinical outcomes in patients with gastrointestinal cancer in palliative care. A total of 59 patients with gastrointestinal cancer who were admitted to Iga City General Hospital were analyzed. Genotyping was conducted using a polymerase chain reaction with confronting two-pair primers. Patients with at least one IL-1RN 2 allele demonstrated a significantly better survival (P=0.0275) while those with IL-6-634 G/G demonstrated a worse survival (P=0.0024). Multivariate analyses using the Cox proportional hazard model revealed that those with at least one IL-1RN 2 allele, IL-6-634 G/G or IL-10-1082 A/G had a significantly elevated adjusted hazard ratio of 9.20 (P=0.014), 41.01 (P=0.001) or 6.49 (P=0.046), respectively, compared with those with each homozygous wild-type polymorphism. In addition, the evaluation of weight loss by genotype revealed the potential influence of IL-10 T-819C genotype (P=0.072). IL-1RN, IL-6 and IL-10 polymorphisms were associated with the survival of patients with gastrointestinal cancer, suggesting the clinical feasibility of genetic testing in patients with gastrointestinal cancer in palliative care.

Keywords: cancer palliative care; cytokines; single nucleotide polymorphisms.

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Figures

Figure 1.
Figure 1.
Survival curve by cytokine genotypes. (A) Survival by IL-1RN VNTR; (B) Survival by IL-6 C-634G; (C) Survival by IL-10 A-1082G. P-values indicate Log-rank P-values. IL, interleukin.
Figure 1.
Figure 1.
Survival curve by cytokine genotypes. (A) Survival by IL-1RN VNTR; (B) Survival by IL-6 C-634G; (C) Survival by IL-10 A-1082G. P-values indicate Log-rank P-values. IL, interleukin.
Figure 1.
Figure 1.
Survival curve by cytokine genotypes. (A) Survival by IL-1RN VNTR; (B) Survival by IL-6 C-634G; (C) Survival by IL-10 A-1082G. P-values indicate Log-rank P-values. IL, interleukin.
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