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. 2019 Jan;10(1):101-104.
doi: 10.3892/mco.2018.1754. Epub 2018 Oct 30.

Basal cell carcinoma of the prostate: A case report and review of the literature

Tadamasa Shibuya  1   2 , Go Takahashi  1   2 , Tomoko Kan  1
Affiliations

Basal cell carcinoma of the prostate: A case report and review of the literature

Tadamasa Shibuya et al. Mol Clin Oncol. 2019 Jan.

Abstract

Basal cell carcinoma (BCC) of the prostate is a rare tumor exhibiting various morphological characteristics, and its progression varies from an indolent to an aggressive type, with local recurrence or distant metastasis. We herein report the case of a patient who was diagnosed with early-stage BCC of the prostate and treated by surgery. A 68 year-old-man visited our hospital for a follow-up for bladder cancer. In August 2017, his serum prostate-specific-antigen (PSA) level was measured to be 5.61 ng/ml and prostate biopsy was performed. Histological examination revealed BCC of the prostate, with immunostaining examination of tumor cells showing positive results for p63 but negative results for PSA. Imaging examination showed no metastasis. Retropubic radical prostatectomy with extended lymph node dissection was performed. Pathological examination of the surgical specimen revealed coexistence of a predominant basaloid component and an adenoid cystic-like tumor with cribriform appearance. There was no extracapsular infiltration or lymph node metastasis. The patient remained alive and recurrence-free after 1 year of follow-up.

Keywords: basal cell carcinoma of the prostate; radical prostatectomy.

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Figures

Figure 1.
Figure 1.
Histological examination of hematoxylin and eosin-stained sections of the biopsy specimen of the prostate showing (A) small nests of the basaloid component in a small part of the specimen (magnification, ×40) and (B) neoplastic cells with round nuclei and scant cytoplasm forming small nests with a peripheral palisading pattern (magnification, ×200). Immunostaining of the biopsy specimen of the prostate showing the neoplastic cells were (C) positive for p63 and (D) negative for prostate-specific antigen (magnification for each, ×200).
Figure 2.
Figure 2.
Axial magnetic resonance imaging-T2 weighted image showing absence of an obvious mass lesion of the prostate.
Figure 3.
Figure 3.
(A) Examination of the surgical specimen of the prostate revealed a carcinoma with a predominant basaloid cell component and (B) an adenoid cystic-like tumor with cribriform appearance. Hematoxylin and eosin staining; magnification, (A) ×40 and (B) ×200.
See this image and copyright information in PMC

References

    1. McKenney JK, Amin MB, Srigley JR, Jimenez RE, Ro JY, Grignon DJ, Young RH. Basal cell proliferations of the prostate other than usual basal cell hyperplasia: A clinicopathologic study of 23 cases, including four carcinomas, with a proposed classification. Am J Surg Pathol. 2004;28:1289–1298. doi: 10.1097/01.pas.0000138180.95581.e1. - DOI - PubMed
    1. Iczkowski KA, Ferguson KL, Grier DD, Hossain D, Banerjee SS, McNeal JE, Bostwick DG. Adenoid cystic/basal cell carcinoma of the prostate: Clinicopathologic findings in 19 cases. Am J Surg Pathol. 2003;27:1523–1529. doi: 10.1097/00000478-200312000-00004. - DOI - PubMed
    1. Ayyathurai R, Civantos F, Soloway MS, Manoharan M. Basal cell carcinoma of the prostate: Current concepts. BJU Int. 2007;99:1345–1349. doi: 10.1111/j.1464-410X.2007.06857.x. - DOI - PubMed
    1. Begnami MD, Quezado M, Pinto P, Linehan WM, Merino M. Adenoid cystic/basal cell carcinoma of the prostate: Review and update. Arch Pathol Lab Med. 2007;131:637–640. - PubMed
    1. Ali TZ, Epstein JI. Basal cell carcinoma of the prostate: A clinicopathologic study of 29 cases. Am J Surg Pathol. 2007;31:697–705. doi: 10.1097/01.pas.0000213395.42075.86. - DOI - PubMed