Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2018 Nov 10;7(1):24-26.
doi: 10.1002/ccr3.1528. eCollection 2019 Jan.

Clinically silent indolent T-cell leukemia

Affiliations
Case Reports

Clinically silent indolent T-cell leukemia

Clément Janot et al. Clin Case Rep. .

Abstract

The clinically silent, symptom-free T-cell prolymphocytic leukemia case that we report here confirms the major interest of the analysis of the blood smear as usual care of any emergent lymphocytosis. It also brings out the issue of the monitoring and follow-up of this uncommon presentation.

Keywords: Cellular hematology; T‐cell leukemia; T‐cell prolymphocytic leukemia; indolent; lymphoid neoplasms.

PubMed Disclaimer

Figures

Figure 1
Figure 1
(A) A microphotograph of the blood smear showing small lymphoid cells with dense chromatin. Their nucleoli and their cytoplasmic expansions suggested the hypothesis of a T‐prolymphocytic neoplasm. (B) Complex karyotype involving no less than six pairs of chromosomes, forming a typical profile of T‐PLL. (C) FISH analysis.

References

    1. Craig, F. E. , and Foon K. A.. 2008. Flow cytometric immunophenotyping for hematologic neoplasms. Blood 111:3941–3967. - PubMed
    1. Pekarsky, Y. , Hallas C., and Croce C. M.. 2001. Molecular basis of mature T‐cell leukemia. JAMA 286:2308–2314. - PubMed
    1. Stankovic, T. , Taylor A. M., and Yuille M. R.. 2001. Recurrent ATM mutations in T‐PLL on diverse haplotypes: no support for their germline origin. Blood 97:1517–1518. - PubMed
    1. Jain, P. , et al. 2017. Annals of oncology : official journal of the European Society for Medical Oncology. Characteristics, outcomes, prognostic factors and treatment of patients with T‐cell prolymphocytic leukemia (T‐PLL) Ann Oncol. 28:1554‐1559. - PMC - PubMed
    1. Garand, R. , Goasguen J., Brizard A., Buisine J., Charpentier A., FranÇois Claisse J., et al. 1998. Indolent course as a relatively frequent presentation in T‐prolymphocytic leukaemia. Br. J. Haematol. 103:488–494. - PubMed

Publication types