Helios-controller of Treg stability and function

Affiliations

¹ Division of Immunobiology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center and the University of Cincinnati, Cincinnati, OH 45229, USA.

Comment

Claire Chougnet et al. Transl Cancer Res. 2016 Aug.

. 2016 Aug;5(Suppl 2):S338-S341.

doi: 10.21037/tcr.2016.07.37.

¹ Division of Immunobiology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center and the University of Cincinnati, Cincinnati, OH 45229, USA.

No abstract available

Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Stable inhibitory activity of regulatory T cells requires the transcription factor Helios.
Kim HJ, Barnitz RA, Kreslavsky T, Brown FD, Moffett H, Lemieux ME, Kaygusuz Y, Meissner T, Holderried TA, Chan S, Kastner P, Haining WN, Cantor H. Kim HJ, et al. Science. 2015 Oct 16;350(6258):334-9. doi: 10.1126/science.aad0616. Science. 2015. PMID: 26472910 Free PMC article.

1. Hahm K, Cobb BS, McCarty AS, et al. Helios, a T cell-restricted Ikaros family member that quantitatively associates with Ikaros at centromeric heterochromatin. Genes Dev 1998;12:782–96. - PMC - PubMed
1. Kelley CM, Ikeda T, Koipally J, et al. Helios, a novel dimerization partner of Ikaros expressed in the earliest hematopoietic progenitors. Curr Biol 1998;8:508–15. - PubMed
1. Antica M, Cicin-Sain L, Kapitanovic S, et al. Aberrant Ikaros, Aiolos, and Helios expression in Hodgkin and non-Hodgkin lymphoma. Blood 2008;111:3296–7. - PubMed
1. Fujii K, Ishimaru F, Nakase K, et al. Over-expression of short isoforms of Helios in patients with adult T-cell leukaemia/lymphoma. Br J Haematol 2003;120:986–9. - PubMed
1. Sun L, Kerawalla H, Wu X, et al. Expression of a unique helios isoform in human leukemia cells. Leuk Lymphoma 2002;43:841–9. - PubMed