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. 1988;30(5-6):275-8.

In vitro effects of B cell growth and maturation factor on B-CLL lymphocytes

S Karray  1 , D Emilie, P Galanaud
Affiliations
  • PMID: 3065728

In vitro effects of B cell growth and maturation factor on B-CLL lymphocytes

S Karray et al. Nouv Rev Fr Hematol (1978). 1988.

Abstract

In the presence of anti-mu Ab, B-CLL lymphocytes are able to respond to cytokines such as IL2, BCGF and IFN-alpha. IL2 is most frequently an active factor. According to the B-CLL lymphocytes population, IL2 alone can induce growth or maturation of B cells. IFN-gamma and IL2 are inefficient on B-CLL lymphocyte proliferation, but they can profoundly modulate the response to IL2. IFN-gamma can synergize with IL2. In contrast IL4 profoundly and constantly inhibits the response to IL2.

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