. 2019 Jan;22(1):e25218.

doi: 10.1002/jia2.25218.

Research priorities to inform "Treat All" policy implementation for people living with HIV in sub-Saharan Africa: a consensus statement from the International epidemiology Databases to Evaluate AIDS (IeDEA)

Marcel Yotebieng¹, Ellen Brazier^{2

3}, Diane Addison^{2

3}, April D Kimmel⁴, Morna Cornell⁵, Olivia Keiser⁶, Angela M Parcesepe⁷, Amobi Onovo⁷, Kathryn E Lancaster¹, Barbara Castelnuovo⁸, Pamela M Murnane⁹, Craig R Cohen¹⁰, Rachel C Vreeman¹¹, Mary-Ann Davies¹², Stephany N Duda¹³, Constantin T Yiannoutsos¹⁴, Rose S Bono⁴, Robert Agler¹, Charlotte Bernard¹⁵, Jennifer L Syvertsen¹⁶, Jean d'Amour Sinayobye¹⁷, Radhika Wikramanayake^{2

3}, Annette H Sohn¹⁸, Per M von Groote¹⁹, Gilles Wandeler¹⁹, Valeriane Leroy²⁰, Carolyn F Williams²¹, Kara Wools-Kaloustian²², Denis Nash^{2

3}; IeDEA Treat All in sub-Saharan Africa Consensus Statement Working Group

Collaborators, Affiliations

Collaborators

IeDEA Treat All in sub-Saharan Africa Consensus Statement Working Group:
Keri Althoff, Craig R Cohen, Geraldina Dominguez, Stephany N Duda, Aimee Freeman, Antoine Jaquet, April D Kimmel, Kathryn E Lancaster, Janne Markus, Rosemary McKaig, Pamela M Murnane, Dominique Nsonde, Angela M Parcesepe, Per M von Groote, Rachel C Vreeman, Carolyn F Williams, Constantin Yiannoutsos

Affiliations

¹ The Ohio State University, Columbus, OH, USA.
² Institute for Implementation Science in Population Health, City University of New York, New York, NY, USA.
³ Department of Epidemiology and Biostatistics, Graduate School of Public Health and Health Policy, City University of New York, New York, NY, USA.
⁴ Department of Health Behavior and Policy, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.
⁵ Centre for Infectious Disease Epidemiology& Research, School of Public Health & Family Medicine, University of Cape Town, Cape Town, South Africa.
⁶ Institute of Global Health, University of Geneva, Geneva, Switzerland.
⁷ University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
⁸ Infectious Diseases Institute, Makerere University, Kampala, Uganda.
⁹ Center for AIDS Prevention Studies, Department of Medicine, University of California San Francisco, San Francisco, CA, USA.
¹⁰ Department of Obstetrics, Gynecology & Reproductive Sciences, Bixby Center for Global Reproductive Health, University of California San Francisco, San Francisco, CA, USA.
¹¹ Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA.
¹² School of Public Health and Family Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
¹³ Vanderbilt University School of Medicine, Nashville, TN, USA.
¹⁴ Fairbanks School of Public Health, Indianapolis, IN, USA.
¹⁵ Inserm, Centre INSERM U1219-Epidémiologie-Biostatistique, School of Public Health (ISPED), University of Bordeaux, Bordeaux, France.
¹⁶ Department of Anthropology, University of California at Riverside, Riverside, CA, USA.
¹⁷ Rwanda Military Hospital, Kigali, Rwanda.
¹⁸ TREAT Asia, amfAR - The Foundation for AIDS Research, Bangkok, Thailand.
¹⁹ Institute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland.
²⁰ Inserm (French Institute of Health and Medical Research), UMR 1027 Université Toulouse 3, Toulouse, France.
²¹ Epidemiology Branch, Division of AIDS at National Institute of Allergy and Infectious Diseases (NIAID), National Institute of Health (NIH), Rockville, MD, USA.
²² Indiana University School of Medicine, Indianapolis, IN, USA.

PMID: 30657644
PMCID: PMC6338103
DOI: 10.1002/jia2.25218

Research priorities to inform "Treat All" policy implementation for people living with HIV in sub-Saharan Africa: a consensus statement from the International epidemiology Databases to Evaluate AIDS (IeDEA)

Marcel Yotebieng et al. J Int AIDS Soc. 2019 Jan.

. 2019 Jan;22(1):e25218.

doi: 10.1002/jia2.25218.

Authors

Collaborators

IeDEA Treat All in sub-Saharan Africa Consensus Statement Working Group:
Keri Althoff, Craig R Cohen, Geraldina Dominguez, Stephany N Duda, Aimee Freeman, Antoine Jaquet, April D Kimmel, Kathryn E Lancaster, Janne Markus, Rosemary McKaig, Pamela M Murnane, Dominique Nsonde, Angela M Parcesepe, Per M von Groote, Rachel C Vreeman, Carolyn F Williams, Constantin Yiannoutsos

Affiliations

¹ The Ohio State University, Columbus, OH, USA.
² Institute for Implementation Science in Population Health, City University of New York, New York, NY, USA.
³ Department of Epidemiology and Biostatistics, Graduate School of Public Health and Health Policy, City University of New York, New York, NY, USA.
⁴ Department of Health Behavior and Policy, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.
⁵ Centre for Infectious Disease Epidemiology& Research, School of Public Health & Family Medicine, University of Cape Town, Cape Town, South Africa.
⁶ Institute of Global Health, University of Geneva, Geneva, Switzerland.
⁷ University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
⁸ Infectious Diseases Institute, Makerere University, Kampala, Uganda.
⁹ Center for AIDS Prevention Studies, Department of Medicine, University of California San Francisco, San Francisco, CA, USA.
¹⁰ Department of Obstetrics, Gynecology & Reproductive Sciences, Bixby Center for Global Reproductive Health, University of California San Francisco, San Francisco, CA, USA.
¹¹ Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA.
¹² School of Public Health and Family Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
¹³ Vanderbilt University School of Medicine, Nashville, TN, USA.
¹⁴ Fairbanks School of Public Health, Indianapolis, IN, USA.
¹⁵ Inserm, Centre INSERM U1219-Epidémiologie-Biostatistique, School of Public Health (ISPED), University of Bordeaux, Bordeaux, France.
¹⁶ Department of Anthropology, University of California at Riverside, Riverside, CA, USA.
¹⁷ Rwanda Military Hospital, Kigali, Rwanda.
¹⁸ TREAT Asia, amfAR - The Foundation for AIDS Research, Bangkok, Thailand.
¹⁹ Institute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland.
²⁰ Inserm (French Institute of Health and Medical Research), UMR 1027 Université Toulouse 3, Toulouse, France.
²¹ Epidemiology Branch, Division of AIDS at National Institute of Allergy and Infectious Diseases (NIAID), National Institute of Health (NIH), Rockville, MD, USA.
²² Indiana University School of Medicine, Indianapolis, IN, USA.

PMID: 30657644
PMCID: PMC6338103
DOI: 10.1002/jia2.25218

Abstract

Introduction: "Treat All" - the treatment of all people with HIV, irrespective of disease stage or CD4 cell count - represents a paradigm shift in HIV care that has the potential to end AIDS as a public health threat. With accelerating implementation of Treat All in sub-Saharan Africa (SSA), there is a need for a focused agenda and research to identify and inform strategies for promoting timely uptake of HIV treatment, retention in care, and sustained viral suppression and addressing bottlenecks impeding implementation.

Methods: The Delphi approach was used to develop consensus around research priorities for Treat All implementation in SSA. Through an iterative process (June 2017 to March 2018), a set of research priorities was collectively formulated and refined by a technical working group and shared for review, deliberation and prioritization by more than 200 researchers, implementation experts, policy/decision-makers, and HIV community representatives in East, Central, Southern and West Africa.

Results and discussion: The process resulted in a list of nine research priorities for generating evidence to guide Treat All policies, implementation strategies and monitoring efforts. These priorities highlight the need for increased focus on adolescents, men, and those with mental health and substance use disorders - groups that remain underserved in SSA and for whom more effective testing, linkage and care strategies need to be identified. The priorities also reflect consensus on the need to: (1) generate accurate national and sub-national estimates of the size of key populations and describe those who remain underserved along the HIV-care continuum; (2) characterize the timeliness of HIV care and short- and long-term HIV care continuum outcomes, as well as factors influencing timely achievement of these outcomes; (3) estimate the incidence and prevalence of HIV-drug resistance and regimen switching; and (4) identify cost-effective and affordable service delivery models and strategies to optimize uptake and minimize gaps, disparities, and losses along the HIV-care continuum, particularly among underserved populations.

Conclusions: Reflecting consensus among a broad group of experts, researchers, policy- and decision-makers, PLWH, and other stakeholders, the resulting research priorities highlight important evidence gaps that are relevant for ministries of health, funders, normative bodies and research networks.

Keywords: 90-90-90 targets; Treat All; implementation science; sub-Saharan Africa; universal HIV treatment.

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Figures

**Figure 1**
Uptake of national ‘Treat all’ policies for adults and adolescents with HIV, July 2017. (Source: WHO)

**Figure 2**
Consensus development process.

See this image and copyright information in PMC

References

1. World Health Organization . Guideline on when to start antiretroviral therapy and on pre‐exposure prophylaxis for HIV. Geneva: World Health Organization; 2015. - PubMed
1. Nash D, Yotebieng M, Sohn AH. Treating all people living with HIV in sub‐Saharan Africa: a new era calling for new approaches. J Virus Erad. 2018;4(Suppl 2):1–4. - PMC - PubMed
1. UNAIDS . 90‐90‐90: on the right track towards the global target. Geneva: Switzerland; 2016.
1. Agyepong IA, Sewankambo N, Binagwaho A, Coll‐Seck AM, Corrah T, Ezeh A, et al. The path to longer and healthier lives for all Africans by 2030: the Lancet Commission on the future of health in sub‐Saharan Africa. Lancet. 2018;390(10114):2803–59. - PubMed
1. Vos T, Abajobir AA, Abate KH, Abbafati C, Abbas KM, Abd‐Allah F, et al. Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries: a systematic analysis for the Global Burden of Disease Study 2016. Lancet. 2017;390(10100):1211–59. - PMC - PubMed

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Research priorities to inform "Treat All" policy implementation for people living with HIV in sub-Saharan Africa: a consensus statement from the International epidemiology Databases to Evaluate AIDS (IeDEA)

Collaborators

Affiliations

Research priorities to inform "Treat All" policy implementation for people living with HIV in sub-Saharan Africa: a consensus statement from the International epidemiology Databases to Evaluate AIDS (IeDEA)

Authors

Collaborators

Affiliations

Abstract

Figures

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Medical

Research Materials