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. 2019 Jan 18;14(1):e0210320.
doi: 10.1371/journal.pone.0210320. eCollection 2019.

Circulating irisin levels in heart failure with preserved or reduced ejection fraction: A pilot study

Andrea Silvestrini  1 , Carmine Bruno  2 , Edoardo Vergani  2 , Angela Venuti  3 , Angela Maria Rita Favuzzi  3 , Francesco Guidi  4 , Nicola Nicolotti  5 , Elisabetta Meucci  1 , Alvaro Mordente  1 , Antonio Mancini  2
Affiliations

Circulating irisin levels in heart failure with preserved or reduced ejection fraction: A pilot study

Andrea Silvestrini et al. PLoS One. .

Abstract

Irisin, a recently discovered myokine, has been considered a prognostic factor in several cardiovascular diseases. Nevertheless, no data are available on the role of irisin in patients with heart failure (HF), both with preserved (HFpEF) or reduced (HFrEF) ejection fraction. We have therefore evaluated the circulating irisin levels in HFpEF and HFrEF patients, correlating them with metabolic parameters and total antioxidant capacity (TAC), as index of oxidative stress. Irisin was significantly higher in HFpEF than in HFrEF patients (7.72 ± 0.76 vs 2.77 ± 0.77 ng/ml, respectively). An inverse correlation between irisin and TAC was found in HFpEF, but not in HFrEF. Conversely, no correlation was present with HOMA index. These data support the hypothesis that a different pathophysiological mechanism is involved in the two HF subtypes, and oxidative stress modulates irisin secretion.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Irisin levels in patients with heart failure with reduced (HFrEF) and preserved (HFpEF) ejection fraction.
Left panel shows a Box-Plot comparing irisin levels in HFpEF with that in HFrEF (* p < 0.05). Right panel shows the correlation between irisin levels and TAC (in sec) in HFpEF.
See this image and copyright information in PMC

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