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. 2019 Apr:29:23-25.
doi: 10.1016/j.msard.2019.01.008. Epub 2019 Jan 3.

2017 McDonald criteria for multiple sclerosis: Earlier diagnosis with reduced specificity?

Francesca Gobbin  1 , Mattia Zanoni  2 , Antonio Marangi  2 , Riccardo Orlandi  2 , Laura Crestani  3 , Maria Donata Benedetti  2 , Alberto Gajofatto  2
Affiliations

2017 McDonald criteria for multiple sclerosis: Earlier diagnosis with reduced specificity?

Francesca Gobbin et al. Mult Scler Relat Disord. 2019 Apr.

Abstract

Background: McDonald criteria for multiple sclerosis (MS) diagnosis were revised in 2017.

Objective: Aim of our study was to evaluate and compare the sensitivity and specificity of 2017 and 2010 McDonald criteria in patients presenting with an initial demyelinating event (IDE).

Methods: We retrospectively identified patients with an IDE and collected clinical, MRI and CSF data in order to demonstrate fulfilment of 2010 and 2017 McDonald criteria.

Results: 2017 McDonald criteria showed 100% (86.8-100%) sensitivity and 13.8% (3.9-31.7%) specificity.

Conclusion: 2017 McDonald criteria appear to have higher sensitivity but reduced specificity compared to 2010 McDonald criteria.

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