Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Jan 18;19(1):7.
doi: 10.1186/s12880-019-0306-8.

The role of ultrasound in the diagnosis of the coexistence of primary hyperparathyroidism and non-medullary thyroid carcinoma

Jian Shen  1 , Qiong Wu  1 , Yan Wang  2
Affiliations

The role of ultrasound in the diagnosis of the coexistence of primary hyperparathyroidism and non-medullary thyroid carcinoma

Jian Shen et al. BMC Med Imaging. .

Abstract

Background: The coexistence of primary hyperparathyroidism(PHPT) and papillary thyroid cancer(PTC) is a known entity; it is a rare and complicated setting for diagnostic imaging.

Methods: After reviewing clinical data of 112 patients who had been treated for PHPT in our facility between January 2015 and December 2017, we identified 7 non-medullary thyroid carcinoma (NMTC) (6.25%). All of them had taken an ultrasound scan and undergone operation. In addition, we have also reviewed relevant reports from other facilities addressing PHPT and NMTC (Mainly PTC).

Results: The 7 NMTCs were all pathologically confirmed PTC in our study, and they consisted of 6 parathyroid adenomas and 1 parathyroid carcinoma. 1 of the 7 patients had 2 malignant PTC nodules with neck lymph node metastasis, the rest 6 had single-focal PTC. Processing previous report data supported an association between PHPT and PTC, although the coexistence of PHPT and PTC is rare, but it does happen. Ultrasound, as an effective examination, would help screen the simultaneous lesions before operation, thus to avoid second surgery if not observed for both diseases at initial stage.

Conclusions: Ultrasound is a necessary choice for preoperative localization, because it has the ability to simultaneously examine the thyroid and parathyroid lesions.

Keywords: Papillary thyroid carcinoma; Preoperative localization; Primary hyperparathyroidism; Ultrasound.

PubMed Disclaimer

Conflict of interest statement

Ethics approval and consent to participate

The study was approved by Ethics Committee of Shanghai Sixth People’s Hospital. All procedures performed in the study involving human participants were in accordance with the ethical standards of the institutional research committee and the declaration of Helsinki. Formal consent is not required for this type of study.

Consent for publication

Written informed consent was obtained from patients for publication of this article and accompanying images. A copy of the written consent is available for review by Editor-in Chief of this journal.

Competing interests

The authors declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
Cervical ultrasonography of a 50-year-old female patient. a and b showed a hypoechoic thyroid nodule measuring 11 mm× 7 mm near the inferior pole of the left thyroid lobe with irregular form, unclear border, micro-calcification. Little blood signal was detected in CDFI mode. c and d showed a hypoechoic right superior parathyroid lesion. Rich color blood flow signal was detected. The pathological results were papillary thyroid micro-carcinoma and parathyroid adenoma respectively
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Fau OP, Black BM. Primary hyperparathyroidism and papillary adenocarcinoma of the thyroid; report of four cases. 1956. - PubMed
    1. Lehwald N, Cupisti K, Krausch M, Ahrazoglu M, Raffel A, Knoefel WT. Coincidence of primary hyperparathyroidism and nonmedullary thyroid carcinoma. Horm Metab Res. 2013;45(9):660–663. doi: 10.1055/s-0033-1345184. - DOI - PubMed
    1. Wilson SD, Doffek KM, Wang TS, Krzywda EA, Evans DB, Yen TW. Primary hyperparathyroidism with a history of head and neck irradiation: the consequences of associated thyroid tumors. Surgery. 2011;150(4):869–877. doi: 10.1016/j.surg.2011.07.046. - DOI - PubMed
    1. Haugen BR, Alexander EK, Bible KC, Doherty GM, Mandel SJ, Nikiforov YE, et al. American Thyroid Association management guidelines for adult patients with thyroid nodules and differentiated thyroid Cancer: the American Thyroid Association guidelines task force on thyroid nodules and differentiated thyroid Cancer. Thyroid. 2015;2015:1557–9077. - PMC - PubMed
    1. Aşik M, Anaforoǧlu I, Köse M, Karyagar S, Mollamehmetoǧlu B, Algün E. Papillary thyroid carcinoma with primary hyperparathyroidism: a report of two cases and a brief literature review. Turkish J Endocrinol Metab. 2013;17(1):12–14. doi: 10.4274/Tjem.2237. - DOI

Publication types

MeSH terms