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. 2019 Jan 18;20(1):20.
doi: 10.1186/s12881-018-0736-0.

Correlation between Interleukin-17 gene polymorphism and osteoarthritis susceptibility in Han Chinese population

Yuming Bai  1   2 , Shijun Gao  3 , Ying Liu  4 , Shengli Jin  2 , Haisen Zhang  2 , Ke Su  2
Affiliations

Correlation between Interleukin-17 gene polymorphism and osteoarthritis susceptibility in Han Chinese population

Yuming Bai et al. BMC Med Genet. .

Abstract

Background: Interleukin-17 (IL-17), a pleiotropic cytokine, plays a significant role in the inflammatory diseases. By a pilot study with small population, IL-17 polymorphisms (IL-17A rs2275913 and IL-17F rs763780) showed a more potential risk factor in knee osteoarthritis (OA) in our recruited subjects. In the current study, the association between IL-17A rs2275913 and IL-17F rs763780and the risk of OA in a Chinese population is studied.

Methods: The IL-17A rs2275913 and IL-17F rs763780 polymorphisms were determined in 594 knee OA cases and 576 healthy controls, using polymerase chain reaction-restriction fragment length polymorphism assay. The relationship between genotype distribution and disease risk, as well as OA severity was analyzed by Chi-square test and multivariate logistic regression.

Results: The experimental results indicated that the polymorphism in IL-17 gene rs2275913 site were related to knee OA risk after the adjustment of BMI, sex, age, smoking and drinking status (AA vs. GG: odds ratio (OR), 1.411; 95% confidence interval (CI), 1.021-1.950; P = 0.040; A allele vs. G allele: OR, 1.192; P = 0.037; 95% CI, 1.012-1.404;). Similarly, subjects who are bearing the rs763780 variant genotypes (TC and CC) and C allele also had a higher susceptibility to knee OA compared with those who are bearing the TT genotype (TC vs. TT, OR: 1.312; P = 0.039; 95% CI: 1.017-1.692; CC vs. TT, OR: 2.812, P = 0.006, 95% CI: 1.338-5.909; C allele Vs. T allele, OR:1.413, P = 0.002, 95% CI:1.141-1.751). In the meantime, one high-risk haplotypes, AC (OR was 7.22, P < 0.01) was found. Both two polymorphisms do not correlated with OA severity based on Kellgren-Lawrence (K&L) scales. Finally, serum IL-17 levels of knee OA patients were greatly higher than those of controls (P = 0.001).

Conclusions: With the limited size sample, our study shows that IL-17 gene polymorphisms possibly related to the high-risk knee OA occurrence.

Keywords: IL-17A; IL-17F; Inflammation; Osteoarthritis; Polymorphism.

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Conflict of interest statement

Ethics approval and consent to participate

This study is followed with all criteria adhered to the Declaration of Helsinki, and has been permitted by the Ethics and Research Committee of the Central Hospital of Cangzhou City, China. All participants signed an informed consent letter.

Consent for publication

Not Applicable.

Competing interests

The authors declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
Representive photos of different severity of knee OA based on Kellgren-Lawrence (K&L) scale (from stage 0 to stage 4)
See this image and copyright information in PMC

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