Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2020 Feb;69(2):397-398.
doi: 10.1136/gutjnl-2018-318036. Epub 2019 Jan 18.

Reduced efficacy of low FODMAPs diet in patients with IBS-D carrying sucrase-isomaltase (SI) hypomorphic variants

Tenghao Zheng  1   2 , Shanti Eswaran  3 , Amanda L Photenhauer  3 , Juanita L Merchant  4 , William D Chey #  3 , Mauro D'Amato #  1   2   5   6
Affiliations
Randomized Controlled Trial

Reduced efficacy of low FODMAPs diet in patients with IBS-D carrying sucrase-isomaltase (SI) hypomorphic variants

Tenghao Zheng et al. Gut. 2020 Feb.
No abstract available

Keywords: carbohydrates; genetic polymorphisms; irritable bowel syndrome.

PubMed Disclaimer

Conflict of interest statement

Competing interests: The project has been partially supported by an unrestricted research grant from QOL Medical to MD’A.

Figures

Figure 1
Figure 1
Decreased symptom relief in patients with IBS and diarrhoea carrying sucrase-isomaltase (SI) hypomorphic variants. Adequate symptom relief in low fermentable oligo-, di-, mono-saccharides and polyols treated individuals, stratified according to SI genotype into carriers and non-carriers of hypomorphic variants. *P=0.031 (one-tailed logistic regression analysis, adjusting for age, sex, body mass index and ethnicity).
See this image and copyright information in PMC

References

    1. Henström M, Diekmann L, Bonfiglio F, et al. . Functional variants in the sucrase-isomaltase gene associate with increased risk of irritable bowel syndrome. Gut 2018;67:263–70. 10.1136/gutjnl-2016-312456 - DOI - PMC - PubMed
    1. Thingholm L, Rühlemann M, Wang J, et al. . Sucrase-isomaltase 15Phe IBS risk variant in relation to dietary carbohydrates and faecal microbiota composition. Gut 2019;68:177–8. 10.1136/gutjnl-2017-315841 - DOI - PMC - PubMed
    1. Garcia-Etxebarria K, Zheng T, Bonfiglio F, et al. . Increased prevalence of rare sucrase-isomaltase pathogenic variants in irritable bowel syndrome patients. Clin Gastroenterol Hepatol 2018;16:1673–6. 10.1016/j.cgh.2018.01.047 - DOI - PMC - PubMed
    1. Gericke B, Amiri M, Naim HY. The multiple roles of sucrase-isomaltase in the intestinal physiology. Mol Cell Pediatr 2016;3:2 10.1186/s40348-016-0033-y - DOI - PMC - PubMed
    1. De Giorgio R, Volta U, Gibson PR, et al. . gluten and FODMAPs in IBS: facts or fiction? Gut 2016;65:169–78. - PubMed

Publication types

Substances