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Practice Guideline
. 2019 Jan;17(1):12-20.
doi: 10.6004/jnccn.2019.0002.

NCCN Guidelines Insights: Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma, Version 2.2019

William G Wierda, John C Byrd, Jeremy S Abramson, Syed F Bilgrami, Greg Bociek, Danielle Brander, Jennifer Brown, Asher A Chanan-Khan, Julio C Chavez, Steve E Coutre, Randall S Davis, Christopher D Fletcher, Brian Hill, Brad S Kahl, Manali Kamdar, Lawrence D Kaplan, Nadia Khan, Thomas J Kipps, Shuo Ma, Sami Malek, Anthony Mato, Claudio Mosse, Vishala T Neppalli, Mazyar Shadman, Tanya Siddiqi, Deborah Stephens, Nina Wagner, Mary A Dwyer, Hema Sundar
Practice Guideline

NCCN Guidelines Insights: Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma, Version 2.2019

William G Wierda et al. J Natl Compr Canc Netw. 2019 Jan.

Abstract

Chronic lymphocytic leukemia (CLL) is generally characterized by an indolent disease course. Histologic transformation (also known as Richter's transformation) to more aggressive lymphomas, such as diffuse large B-cell lymphoma or Hodgkin lymphoma, occurs in approximately 2% to 10% of patients and is associated with a poor prognosis. These NCCN Guidelines Insights discuss the recommendations for the diagnosis and management of patients with histologic transformation.

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