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Review
. 2019;20(6):547-562.
doi: 10.2174/1389203720666190119124846.

A Journey through the Cytoskeleton with Protein Kinase CK2

Claudio D'Amore  1 , Valentina Salizzato  1   2 , Christian Borgo  1 , Luca Cesaro  1 , Lorenzo A Pinna  1   2 , Mauro Salvi  1
Affiliations
Review

A Journey through the Cytoskeleton with Protein Kinase CK2

Claudio D'Amore et al. Curr Protein Pept Sci. 2019.

Abstract

Substrate pleiotropicity, a very acidic phosphorylation consensus sequence, and an apparent uncontrolled activity, are the main features of CK2, a Ser/Thr protein kinase that is required for a plethora of cell functions. Not surprisingly, CK2 appears to affect cytoskeletal structures and correlated functions such as cell shape, mechanical integrity, cell movement and division. This review outlines our current knowledge of how CK2 regulates cytoskeletal structures, and discusses involved pathways and molecular mechanisms.

Keywords: Post-translational modifications; acidic phosphorylation; actin; casein kinase 2; septin; tubulin..

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