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Clinical Trial
. 1988 Nov;43(11):937-8.
doi: 10.1136/thx.43.11.937.

Effect of budesonide on pulmonary hyperinflation in young asthmatic children

A Greenough  1 , J Pool, J G Gleeson, J F Price
Affiliations
Clinical Trial

Effect of budesonide on pulmonary hyperinflation in young asthmatic children

A Greenough et al. Thorax. 1988 Nov.

Abstract

In 19 asthmatic children, aged 2-6 years, the effect of six weeks' treatment with inhaled budesonide or placebo on functional residual capacity (FRC--helium dilution) and bronchodilator responsiveness was assessed in a double blind, randomised crossover trial. FRC was increased in most children at the start of treatment. Treatment with budesonide was associated with a reduction in FRC by comparison with placebo (median change 9% v 0%; p less than 0.05). There was a trend towards a greater response to a bronchodilator after budesonide. The results suggest that inhaled corticosteroids reduce hyperinflation in young asthmatic children.

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References

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