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. 2019 May;143(5):1934-1937.e4.
doi: 10.1016/j.jaci.2018.10.071. Epub 2019 Jan 17.

Challenges in assessing the efficacy of systemic corticosteroids for severe wheezing episodes in preschool children

Theresa W Guilbert  1 , Leonard B Bacharier  2 , David T Mauger  3 , Wanda Phipatanakul  4 , Stanley J Szefler  5 , Susan Boehmer  3 , Avraham Beigelman  2 , Anne M Fitzpatrick  6 , Daniel J Jackson  7 , Sachin N Baxi  4 , Mindy Benson  8 , Carey-Ann D Burnham  9 , Michael D Cabana  10 , Mario Castro  2 , James F Chmiel  11 , Ronina Covar  12 , Michael Daines  13 , Jonathan M Gaffin  14 , Deborah A Gentile  15 , Fernando Holguin  16 , Elliot Israel  17 , H William Kelly  18 , Stephen C Lazarus  10 , Robert F Lemanske Jr  7 , Ngoc Ly  19 , Kelley Meade  8 , Wayne Morgan  13 , James Moy  20 , J Tod Olin  12 , Stephen P Peters  21 , Jacqueline A Pongracic  22 , Hengameh H Raissy  18 , Kristie Ross  11 , William J Sheehan  4 , Christine Sorkness  23 , W Gerald Teague  24 , Shannon Thyne  25 , Fernando D Martinez  13 ; National Heart, Lung, and Blood Institute's AsthmaNet
Collaborators, Affiliations

Challenges in assessing the efficacy of systemic corticosteroids for severe wheezing episodes in preschool children

Theresa W Guilbert et al. J Allergy Clin Immunol. 2019 May.

Abstract

This letter addresses the controversial issue of the use of oral corticosteroids during wheezing exacerbations in preschool-aged children by demonstrating findings of a prematurely terminated multi-center clinical trial, discussing lessons learned, and suggesting future directions.

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Figures

Figure 1.
Figure 1.
Number of participants enrolled in OCELOT (Oral Corticosteroids for treating Episodes of significant LOwer respiratory Tract symptoms) trial that received OCELOT treatment (per-protocol) or open-label oral corticosteroids (OCS) outside of the trial (termed early terminators) with or without APRIL treatment.
See this image and copyright information in PMC

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