Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Jan;27(1):133-137.
doi: 10.1016/j.jsps.2018.09.006. Epub 2018 Sep 11.

Investigation the antioxidant activity of benzo[ g]triazoloquinazolines correlated with a DFT study

Abdulrahman A Almehizia  1 , Hatem A Abuelizz  1 , Hanan A A Taie  2 , Anouar ElHassane  3 , Mohamed Marzouk  4 , Rashad Al-Salahi  1
Affiliations

Investigation the antioxidant activity of benzo[ g]triazoloquinazolines correlated with a DFT study

Abdulrahman A Almehizia et al. Saudi Pharm J. 2019 Jan.

Abstract

Previously, a series of 2-phenoxy-benzo[g]triazoloquinazolines 1-16 were synthesized and fully characterized. The antioxidant activity of the target molecules 1-16 was evaluated using three different assays namely 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging, ferric reduction antioxidant power (FRAP) and reducing power capability (RPC). The results revealed that some benzotriazoloquinazolines showed good activity and have the capacity to scavenge free radicals. In particular, compounds 1 and 14 have shown the highest activity. The butylated hydroxyl toluene (BHT) used as standard agent. Density functional theory was carried out to explain the relative importance of C[bond, double bond]O, C[bond, double bond]S and NH groups on the radical scavenging activity of the target benzotriazoloquinazolines. The finding in present study shows that the active compounds can be used as template for further development of more potent antioxidant agents.

Keywords: Antioxidant capacity; BHT; Benzotriazoloquinazolines; DFT; DPPH.

PubMed Disclaimer

Figures

Scheme 1
Scheme 1
The synthetic compounds 1–16.
Scheme 2
Scheme 2
Plausible mechanism for the antioxidant activity of benzotriazloquinazolines 1 and 14.
See this image and copyright information in PMC

References

    1. Abuelizz A.H., El-Dib R.A., Marzouk M., Al-Salahi R. In vitro evaluation of new 2-phenoxy-benzo[g][1,2,4]triazolo[1,5-a]quinazoline derivatives as antimicrobial agents. Microb. Pathog. 2018;117:60–67. - PubMed
    1. Al-Salahi R., Anouar E.H., Marzouk M., Taie H.A., Abuelizz H.A. Screening and evaluation of antioxidant activity of some 1,2,4-triazolo[1,5-a]quinazoline derivatives. Future Med. Chem. 2017;10:379–390. - PubMed
    1. Al-Salahi R., Ashour A., Marzouk M., Kumar A. In Vitro cytotoxicity evaluation of a new series of benzo[g][1,2,4]triazolo[1,5-α]quinazolines. Lat. Am. J. Pharm. 2015;34:1926–1930.
    1. Al-Salahi R., Marzouk M. Synthesis of novel 2-phenoxy benzo[g][1,2,4]triazolo[1,5-a]quinazoline and its derivatives starting with diphenyl-N-cyanoimidocarbonate. Russ. J. Gen. Chem. 2016;86:1741–1746.
    1. Anouar E., Calliste C., Kosinova P., Di Meo F., Duroux J., et al. Free radical scavenging properties of guaiacol oligomers: a combined experimental and quantum study of the guaiacyl-moiety role. J. Phys. Chem. A. 2009;113:13881–13891. - PubMed

LinkOut - more resources