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. 2018 Nov 15;10(11):3443-3454.
eCollection 2018.

Mechanical characterization of 3D printed multi-morphology porous Ti6Al4V scaffolds based on triply periodic minimal surface architectures

Li-Ya Zhu  1   2 , Lan Li  3   4 , Jian-Ping Shi  1   2 , Zong-An Li  1   2 , Ji-Quan Yang  1   2
Affiliations

Mechanical characterization of 3D printed multi-morphology porous Ti6Al4V scaffolds based on triply periodic minimal surface architectures

Li-Ya Zhu et al. Am J Transl Res. .

Abstract

Heterogeneous biomaterials that simultaneously mimic the topological and mechanical properties of nature bone tissues are of great interest in recent years. In this study, multi-morphology porous scaffolds based on the triply periodic minimal surfaces (TPMS) were designed and 3D printed with spatially changing pore patterns. Experiments and numerical analyses were carried out to assess the mechanical properties of the multi-morphology graded porous scaffold. As can be seen from the results, the multi-morphology structure showed a combination of relatively low elastic moduli and high yield strength. This combination allows for simultaneously minimizing the bone damage and increasing the stability of bone-implant interface. Thus the 3D printed multi-morphology porous Ti6AlV scaffold had shown significant promise for orthopedic application.

Keywords: 3D printing; Triply periodic minimal surface; bone tissue engineering; graded porous structure; multi-morphology scaffold.

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Conflict of interest statement

None.

Figures

Figure 1
Figure 1
Some of the basic mathematically defined TPMS structure types: (A) Primitive, (B) Gyroid.
Figure 2
Figure 2
Scaffold modeling: (A) Graded porous structure based on P surface, (B) Porous structure based on G surface, (C) Multi-morphology graded porous structure combing P and G surfaces, (D) Side view of these scaffold models.
Figure 3
Figure 3
Appearance and SEM images (×50) of the printed scaffolds: (A) Graded structure based on P surface, (B) Porous structure based on G surface, (C) Multi-morphology graded structure combing P and G surfaces
Figure 4
Figure 4
Voxel mesh used for FE simulating: (A) Graded structure based on P surface, (B) Porous structure based on G surface, (C) Multi-morphology graded structure combing P and G surfaces.
Figure 5
Figure 5
Experimental stress strain curves.
Figure 6
Figure 6
Simulated stress distribution: (A) Graded structure based on P surface, (B) Porous structure based on G surface, (C) Multi-morphology graded structure combing P and G surfaces.
Figure 7
Figure 7
Bone modeling and meshing. (A) Simplified 3D model of femur bone, (B) Mesh of scaffold bone assembly.
Figure 8
Figure 8
Simulated stress distribution on bone with different porous scaffolds: (A) Gradient structure based on P surface, (B) Porous structure based on G surface, (C) Multi-morphology gradient structure combing P and G surfaces.
See this image and copyright information in PMC

References

    1. Martin JR, Gupta MK, Page JM, Yu F, Davidson JM, Guelcher SA, Duvall CL. A porous tissue engineering scaffold selectively degraded by cell-generated reactive oxygen species. Biomaterials. 2014;35:3766–3776. - PMC - PubMed
    1. Yousefi AM, Hoque ME, Prasad RG, Uth N. Current strategies in multiphasic scaffold design for osteochondral tissue engineering: a review. J Biomed Mater Res A. 2015;103:2460–2481. - PubMed
    1. Yan C, Liang H, Hussein A, Young P. Ti-6Al-4V triply periodic minimal surface structures for bone implants fabricated via selective laser melting. J Mech Behav Biomed Mater. 2015;51:61–73. - PubMed
    1. Li G, Lei W, Wei P, Fei Y, Jiang W, Wu X, Kong X, Dai K, Hao Y. In vitro and in vivo study of additive manufactured porous Ti6Al4V scaffolds for repairing bone defects. Sci Rep. 2016;6:34072. - PMC - PubMed
    1. Parthasarathy J, Starly B, Raman S, Christensen A. Mechanical evaluation of porous titanium (Ti6Al4V) structures with electron beam melting (EBM) J Mech Behav Biomed Mater. 2010;3:249–259. - PubMed

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