Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1988 Dec;58(6):710-4.
doi: 10.1038/bjc.1988.295.

Partial deletion of chromosome 11p in breast cancer correlates with size of primary tumour and oestrogen receptor level

J Mackay  1 , P A Elder, D J Porteous, C M Steel, R A Hawkins, J J Going, U Chetty
Affiliations
Free PMC article

Partial deletion of chromosome 11p in breast cancer correlates with size of primary tumour and oestrogen receptor level

J Mackay et al. Br J Cancer. 1988 Dec.
Free PMC article

Abstract

In a study of DNAs from 100 breast cancer patients and 100 controls, there were no differences in the frequencies of common or rare alleles at the Harvey ras (c-Ha-ras) locus on chromosome 11. However, one Ha-ras allele was deleted from the tumour DNA in 14 of 65 informative patients. Loss of a Ha-ras allele correlates with paucity of oestrogen receptor protein and with increased tumour size at presentation, but is not associated with microscopic evidence of lymph node invasion. The findings on Ha-ras and other informative loci are consistent with the possibility that a tumour suppressor gene involved in the early stages of breast cancer is located on the short arm of chromosome 11.

PubMed Disclaimer

References

    1. Nature. 1986 May 1-7;321(6065):84-5 - PubMed
    1. Proc Natl Acad Sci U S A. 1985 Sep;82(18):6240-4 - PubMed
    1. Cancer Res. 1986 Aug;46(8 Suppl):4233s-4236s - PubMed
    1. Cancer Res. 1986 Sep;46(9):4776-81 - PubMed
    1. J Natl Cancer Inst. 1986 Sep;77(3):697-701 - PubMed

Publication types

Substances