Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2019 Mar;29(3):181-182.
doi: 10.1038/s41422-018-0138-z.

Divide to conquer: NLRP3 is activated on dispersed trans-Golgi network

Kaiwen W Chen #  1 , Dave Boucher #  1 , Petr Broz  2
Affiliations
Comment

Divide to conquer: NLRP3 is activated on dispersed trans-Golgi network

Kaiwen W Chen et al. Cell Res. 2019 Mar.
No abstract available

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Diverse NLRP3 agonists trigger disassembly of the trans-Golgi network (TGN)exposing PI4P microdomains to recruit NLRP3 through its ionic bonding between its polybasic KKKK motif and the negatively charged PtdIns4Ps. NLRP3 aggregates on disassembled TGN and nucleates polymerization of the adaptor protein ASC
See this image and copyright information in PMC

Comment on

References

    1. Broz P, Dixit VM. Nat. Rev. Immunol. 2016;16:407–420. doi: 10.1038/nri.2016.58. - DOI - PubMed
    1. Schroder K, Tschopp J. Cell. 2010;140:821–832. doi: 10.1016/j.cell.2010.01.040. - DOI - PubMed
    1. Chen J, Chen ZJ. Nature. 2018;564:71–76. doi: 10.1038/s41586-018-0761-3. - DOI - PMC - PubMed
    1. Hafner-Bratkovic I, et al. Nat. Commun. 2018;9:5182. doi: 10.1038/s41467-018-07573-4. - DOI - PMC - PubMed
    1. Ding J, et al. Nature. 2016;535:111–116. doi: 10.1038/nature18590. - DOI - PubMed

MeSH terms

Substances