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Clinical Trial
. 2019 May;156(6):1921-1923.e3.
doi: 10.1053/j.gastro.2019.01.033. Epub 2019 Jan 18.

Long-term Outcomes of Fecal Microbiota Transplantation in Patients With Cirrhosis

Jasmohan S Bajaj  1 , Andrew Fagan  2 , Edith A Gavis  2 , Zain Kassam  3 , Masoumeh Sikaroodi  4 , Patrick M Gillevet  4
Affiliations
Clinical Trial

Long-term Outcomes of Fecal Microbiota Transplantation in Patients With Cirrhosis

Jasmohan S Bajaj et al. Gastroenterology. 2019 May.
No abstract available

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: ZK is an employee and shareholder of Finch Therapeutics Group, as well as an advisor for OpenBiome; no other relevant conflicts exist

Figures

Figure 1.
Figure 1.
1A: Schematic of study follow-up, 1B/C: Hepatic encephalopathy episodes and total hospitalizations in SOC compared to FMT in the original study (0–5 months) compared to long-term (>12 months). Comparison is made using Kruskal-Wallis tests between groups. 1D: Median and 95% CI of total Psychometric hepatic encephalopathy score (PHES) at baseline, Day 5 (D5, pre-FMT but post-antibiotics), Day 20 (15 days post-FMT) and >1 yr in the FMT group (green bars) compared to SOC (S, orange bars) showed a better (higher) PHES score post-FMT in the FMT groups compared to SOC at D20 and long-term. 1E: Median and 95% CI of EncephalApp OffTime+OnTime at baseline, day 5 (D5, pre-FMT but post-antibiotics), Day 20 (15 days post-FMT) and >1 yr in the FMT group (green bars) compared to SOC (S, orange bars) showed a better (lower) time required for EncephalApp post-FMT in the FMT groups compared to SOC at D20 and long-term. 1F: Principal component analysis of microbiota in the FMT group pre-FMT, Day 7, Day 15 and long-term follow up showed relative clustering between the post-FMT group microbiota (black oval) compared to pre-FMT (red oval). 1G: On LEFSe, there was a significant increase in relative abundance of Burkholderiaceae and decrease of Acidaminococcaceae in FMT compared to SOC group at study end. SOC group is in red and FMT group is in green
See this image and copyright information in PMC

Comment in

  • Reply.
    Bajaj JS, Gillevet PM. Bajaj JS, et al. Gastroenterology. 2019 Sep;157(3):902-903. doi: 10.1053/j.gastro.2019.07.005. Epub 2019 Jul 11. Gastroenterology. 2019. PMID: 31302141 No abstract available.
  • The Transplantation of Fecal Microbiota for Cirrhotic Patients.
    Lo GH. Lo GH. Gastroenterology. 2019 Sep;157(3):902. doi: 10.1053/j.gastro.2019.06.040. Epub 2019 Jul 12. Gastroenterology. 2019. PMID: 31306634 No abstract available.

References

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    1. Bajaj JS et al. Hepatology 2017.
    1. Ji SK et al. Front Microbiol 2017;8:1208. - PMC - PubMed
    1. Patidar KR et al. Am J Gastroenterol 2014;109:1757–63. - PMC - PubMed

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