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Case Reports
. 2018 Dec;26(4):304-306.

Two Cases of Proximal Subungual Onychomycosis Caused by Trichophyton rubrum in HIV-negative Patients During Treatment with TNF-α Inhibitors Combined with Methotrexate

Pernille Lindsø Andersen, Mattias Arvid Simon Henning, Gregor B E Jemec, Maiken Cavling Arendrup, Ditte Marie Saunte  1
Affiliations
  • PMID: 30665479
Case Reports

Two Cases of Proximal Subungual Onychomycosis Caused by Trichophyton rubrum in HIV-negative Patients During Treatment with TNF-α Inhibitors Combined with Methotrexate

Pernille Lindsø Andersen et al. Acta Dermatovenerol Croat. 2018 Dec.

Abstract

Proximal subungual onychomycosis (PSO) is a rare subtype of onychomycosis with a clinical presentation characterized by proximal leukonychia in the lunular area of the nail. PSO is associated with immunosuppression and regarded a sign of Human Immunodeficiency Virus (HIV) infection when caused by Trichophyton (T.) rubrum. We present two cases of PSO caused by T. rubrum developed during treatment with TNF-α inhibitors combined with methotrexate (MTX).

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