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Comment
. 2019 Feb;95(2):265-267.
doi: 10.1016/j.kint.2018.11.016.

Reimagining the kidney biopsy in the era of diagnostic biomarkers of glomerular disease

Brad H Rovin  1 , Salem Almaani  2 , Ana Malvar  3
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Reimagining the kidney biopsy in the era of diagnostic biomarkers of glomerular disease

Brad H Rovin et al. Kidney Int. 2019 Feb.
Free article

Abstract

Anti-phospholipase A2 receptor (PLA2R) antibody is a specific biomarker for primary membranous nephropathy (MN). Testing positive for anti-PLA2R has been postulated to establish a diagnosis of MN in the absence of a kidney biopsy. Bobart et al. tested this hypothesis and concluded that anti-PLA2R positivity is sufficient to diagnose primary MN and initiate treatment in a subset of patients with nephropathy. This biomarker, however, does not render the kidney biopsy obsolete, but encourages the application of molecular analyses to renal pathology to keep the biopsy relevant.

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