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Comment
. 2019 Feb;68(2):266-267.
doi: 10.2337/dbi18-0038.

In Pursuit of a Biomarker of Weight Gain Susceptibility-Is FGF21 a Candidate?

Leanne M Redman  1 , Eric Ravussin  2
Affiliations
Comment

In Pursuit of a Biomarker of Weight Gain Susceptibility-Is FGF21 a Candidate?

Leanne M Redman et al. Diabetes. 2019 Feb.
No abstract available

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Figures

Figure 1. The hypothesized relationship between energy expenditure, FGF21, and body weight regulation. Stimulating energy expenditure with acute low-protein overfeeding can identify individuals who are able to dissipate the excess calories consumed as heat (“spendthrift”) versus those who cannot (“thrifty”). The magnitude of the increase in plasma concentration of FGF21 in response to acute low-protein overfeeding is positively associated with the acute change in 24-h energy expenditure. Thrifty individuals have an attenuated increase in FGF21 in response to acute low-protein overfeeding and are more susceptible to weight gain over 6 months.
Figure 1
The hypothesized relationship between energy expenditure, FGF21, and body weight regulation. Stimulating energy expenditure with acute low-protein overfeeding can identify individuals who are able to dissipate the excess calories consumed as heat (“spendthrift”) versus those who cannot (“thrifty”). The magnitude of the increase in plasma concentration of FGF21 in response to acute low-protein overfeeding is positively associated with the acute change in 24-h energy expenditure. Thrifty individuals have an attenuated increase in FGF21 in response to acute low-protein overfeeding and are more susceptible to weight gain over 6 months.
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References

    1. Stunkard AJ , Sørensen TI , Hanis C , et al. . An adoption study of human obesity. N Engl J Med 1986;314:193–198 - PubMed
    1. Neumann RO . Experimentelle beiträge zur lehre von dem täglichen nahrungsbedarf des menschen unter besonderer beruck-sichtigung der notwendigen eiweissmenge. Arch Hyg 1902;45:1–87
    1. Stock MJ. Gluttony and thermogenesis revisited. Int J Obes Relat Metab Disord 1999;23:1105–1117 - PubMed
    1. Weyer C, Vozarova B, Ravussin E, Tataranni PA. Changes in energy metabolism in response to 48 h of overfeeding and fasting in Caucasians and Pima Indians. Int J Obes Relat Metab Disord 2001;25:593–600 - PubMed
    1. Reinhardt M , Thearle MS , Ibrahim M , et al. . A human thrifty phenotype associated with less weight loss during caloric restriction. Diabetes 2015;64:2859–2867 - PMC - PubMed