Oropouche Virus-Associated Aseptic Meningoencephalitis, Southeastern Brazil

Abstract

Oropouche fever is a neglected arthropodborne disease and zoonosis responsible for several outbreaks of a febrile disease in Central and South America. We present a clinical case of aseptic meningoencephalitis in an immunocompetent patient that resulted from Oropouche virus acquired in northern Brazil but diagnosed in a nonendemic region.

Keywords: Brazil; Oropouche fever; Oropouche virus; arboviruses; arthropod-borne diseases; mosquitoes; tropical diseases; vector-borne infections; viruses; zoonoses.

Figure

Imaging and PCR results for a 28-year-old man with Oropouche virus infection, southeastern Brazil. A) Cerebral computed tomography showing a cortical edema on the left frontal lobe (white arrow). B) Agarose gel of reverse transcription PCR products of Oropouche virus S fraction. Lane , patient’s serum sample; lane , patient’s cerebrospinal fluid; lane , patient’s leukocyte supernatant; lane , negative control; lane , internal control; lane , positive control.