Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Feb;25(2):316-320.
doi: 10.3201/eid2502.170745.

Clinical Manifestations, Antimicrobial Drug Susceptibility Patterns, and Outcomes in Melioidosis Cases, India

Maria Koshy, Manjeera Jagannati, Ravikar Ralph, Punitha Victor, Thambu David, Sowmya Sathyendra, Balaji Veeraraghavan, George M Varghese

Clinical Manifestations, Antimicrobial Drug Susceptibility Patterns, and Outcomes in Melioidosis Cases, India

Maria Koshy et al. Emerg Infect Dis. 2019 Feb.

Abstract

We studied the clinical manifestations and outcomes of 114 patients with culture-confirmed melioidosis treated at a tertiary hospital in southern India. Diabetes mellitus is the main risk factor, and chronic melioidosis mimicking tuberculosis was more common than acute disease. Septicemia and respiratory involvement were associated with poor outcomes.

Keywords: Burkholderia pseudomallei; India; antimicrobial drug susceptibility; bacteria; clinical manifestations; melioidosis; outcomes.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Distribution of patients with melioidosis, by state, India, 2008–2014.
Figure 2
Figure 2
Trend in melioidosis case-fatality rates, southern India, 2008–2014.
See this image and copyright information in PMC

References

    1. Wiersinga WJ, Currie BJ, Peacock SJ. Melioidosis. N Engl J Med. 2012;367:1035–44. 10.1056/NEJMra1204699 - DOI - PubMed
    1. Dance DAB. Melioidosis. Curr Opin Infect Dis. 2002;15:127–32. 10.1097/00001432-200204000-00005 - DOI - PubMed
    1. Cheng AC, Currie BJ. Melioidosis: epidemiology, pathophysiology, and management. Clin Microbiol Rev. 2005;18:383–416. 10.1128/CMR.18.2.383-416.2005 - DOI - PMC - PubMed
    1. Currie BJ, Ward L, Cheng AC. The epidemiology and clinical spectrum of melioidosis: 540 cases from the 20 year Darwin prospective study. PLoS Negl Trop Dis. 2010;4:e900. 10.1371/journal.pntd.0000900 - DOI - PMC - PubMed
    1. Limmathurotsakul D, Golding N, Dance DA, Messina JP, Pigott DM, Moyes CL, et al. Predicted global distribution of Burkholderia pseudomallei and burden of melioidosis. Nat Microbiol. 2016;1:15008. 10.1038/nmicrobiol.2015.8 - DOI - PubMed

Substances