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. 2019 Jul;102(3):347-350.
doi: 10.1016/j.jhin.2019.01.017. Epub 2019 Jan 19.

Candidaemia in an Irish intensive care unit setting between 2004 and 2018 reflects increased incidence of Candida glabrata

P Ryan  1 , C Motherway  2 , J Powell  2 , A Elsaka  2 , A A Sheikh  2 , A Jahangir  2 , N H O'Connell  3 , C P Dunne  4
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Candidaemia in an Irish intensive care unit setting between 2004 and 2018 reflects increased incidence of Candida glabrata

P Ryan et al. J Hosp Infect. 2019 Jul.

Abstract

The cumulative incidence of candidaemia in an Irish intensive care unit (ICU) setting between January 2004 and August 2018 was 17/1000 ICU admissions. Candida albicans was responsible for 55% (N=41) of cases. C. glabrata (N=21, 28%) was the next most prevalent species, and has been identified most frequently since 2012. C. glabrata was associated with a higher mortality rate (57%) than C. albicans (29%). All isolates were susceptible to caspofungin (0.05 μg/mL). Notably, 37% of C. glabrata isolates were resistant to fluconazole, with 13% resistant to amphotericin B, highlighting the need for prudent antifungal stewardship to impede development of multi-drug-resistant C. glabrata in the ICU setting.

Keywords: Candida albicans; Candida glabrata; ICU; Increased; Prevalence.

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