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Editorial
. 2019 Jan 8:9:1827.
doi: 10.3389/fphys.2018.01827. eCollection 2018.

Editorial: Cross Adaptation and Cross Tolerance in Human Health and Disease

Ben James Lee  1 , Oliver R Gibson  2 , Charles Douglas Thake  3 , Mike Tipton  4 , John A Hawley  5 , James David Cotter  6
Affiliations
Editorial

Editorial: Cross Adaptation and Cross Tolerance in Human Health and Disease

Ben James Lee et al. Front Physiol. .
No abstract available

Keywords: adaptation; dehydration; heat; hypoxia; nutrition; preconditining.

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Figures

Figure 1
Figure 1
Overview of cross-adaptation. Adaptation to one stimulus provides cross tolerance to another (CA1). For example, heat acclimation enhances tolerance to hypoxia, and may enhance exercise performance under temperate conditions. CA2 highlights the combined adaptive effects of two stimuli in providing beneficial responses to a third variable, e.g., heat acclimation alongside exercise training may enhance left ventricular function. The potential for adaptation to one stressor enhancing adaptation to other stressors (CA3), such as the manipulation of nutrient availability to enhance or amplify skeletal muscle responses to training, remains an interesting area for future work. Finally, the use of one stimulus to model the responses to the same or similar stimulus in another circumstance (e.g., high altitude hypoxia as model to examine physiological responses in an intensive care unit) follows the same conceptual premise as cross adaptation.
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  • Editorial on the Research Topic Cross Adaptation and Cross Tolerance in Human Health and Disease

References

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