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. 2019 May;34(5):657-665.
doi: 10.1002/gps.5062. Epub 2019 Feb 28.

The impact of apathy on cognitive performance in the elderly

Genoveva Montoya-Murillo  1 , Naroa Ibarretxe-Bilbao  1 , Javier Peña  1 , Natalia Ojeda  1
Affiliations

The impact of apathy on cognitive performance in the elderly

Genoveva Montoya-Murillo et al. Int J Geriatr Psychiatry. 2019 May.

Abstract

Objectives: To examine the impact of apathy on cognitive performance in the elderly following the conceptual principles proposed by Marin1 and Stuss et al2 and to determine the role of the symptoms of apathy in different cognitive domains.

Methods: Cross-sectional study with a cohort of healthy elderly subjects over 55 years old (n = 140). One hundred forty healthy-elderly subjects (aged 79.24 ± 8.6 years old) were recruited from 12 day centers in Northern Spain. Participants underwent a neuropsychological battery, which evaluated Mini Mental State Examination (MMSE), attention, processing speed, verbal fluency, visual and verbal memory, working memory, and executive functioning. Apathy was assessed by the Lille Apathy Rating Scale (LARS), which is composed of four factors: intellectual curiosity, emotion, action initiation, and self-awareness. Correlation and linear regression analyses were performed.

Results: In the correlational analysis, the LARS total score correlated negatively with global cognition, verbal fluency, and visual and verbal memory. The intellectual curiosity factor correlated negatively with all cognitive domains except attention. The emotion factor correlated negatively with visual memory. No correlation was found between the action initiation and self-awareness factors or any of the cognitive variables. Multiple stepwise regression analysis showed that symptoms of apathy explained cognitive performance in attention, processing speed, verbal fluency, visual and verbal memory, working memory, executive functioning, and MMSE.

Conclusions: Apathy was significantly associated with cognitive performance, especially with the intellectual curiosity factor. Our results suggest that specific symptoms of apathy contribute differently to individual cognitive domains.

Keywords: apathy; cognition; cognitive performance; elderly; motivation; neuropsychology.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Pearson's correlation between cognitive domains and apathy subscales
Figure 2
Figure 2
Multiple stepwise regression analysis of cognitive domains and apathy subscales
See this image and copyright information in PMC

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References

    1. Marin RS. Apathy: A neuropsychiatric syndrome. J Neuropsychiatry Clin Neurosci. 1991;3(3):243‐254. - PubMed
    1. Stuss DT, Van Reekum R, Murphy KJ. Differentiation of states and causes of apathy In: Borod JC, ed. Series in affective science. The neuropsychology of emotion. New York, NY, US: Oxford University Press; 2000:340‐363.
    1. Levy R, Dubois B. Apathy and the functional anatomy of the prefrontal cortex‐basal ganglia circuits. Cereb Cortex. 2006;16(7):916‐928. - PubMed
    1. Fernández‐Matarrubia M, Matías‐Guiu JA, Moreno‐Ramos T, et al. Validation of the lille's apathy rating scale in very mild to moderate dementia. Am J Geriatr Psychiatry. 2016;24(7):517‐527. - PubMed
    1. Grool AM, Geerlings MI, Sigurdsson S, et al. Structural MRI correlates of apathy symptoms in older persons without dementia: AGES‐reykjavik study. Neurol. 2014;82(18):1628‐1635. - PMC - PubMed

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