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Observational Study
. 2019 Feb 15;59(2):63-67.
doi: 10.2176/nmc.oa.2018-0254. Epub 2019 Jan 23.

Probability of Soluble Tissue Factor Release Lead to the Elevation of D-dimer as a Biomarker for Traumatic Brain Injury

Eiichi Suehiro  1 , Yuichi Fujiyama  1 , Miwa Kiyohira  1 , Yukari Motoki  2 , Junzo Nojima  2 , Michiyasu Suzuki  1
Affiliations
Observational Study

Probability of Soluble Tissue Factor Release Lead to the Elevation of D-dimer as a Biomarker for Traumatic Brain Injury

Eiichi Suehiro et al. Neurol Med Chir (Tokyo). .

Abstract

d-dimer is a potential biomarker for the detection of traumatic brain injury (TBI). However, the mechanisms that trigger elevation of d-dimer in TBI remain unclear. The purpose of this study was to evaluate the reliability of d-dimer in blood as a biomarker for TBI and to determine the mechanisms involved in regulating its blood levels. Nine patients with moderate to severe isolated TBI (Glasgow Coma Scale [GCS] score 7-13) were admitted to our hospital from May 2013 to June 2014. Blood samples were collected from systemic arteries on arrival and at 1, 3, 5, and 7 days after injury. Blood levels of neuron specific enolase (NSE), d-dimer, and soluble tissue factor (sTF) were measured. NSE (33.4 ng/ml: normal <12.0 ng/ml) and d-dimer (56.1 μg/ml: normal <1.0 μg/ml) were elevated at admission and declined on day 1 after injury. At admission, there were significant correlations of d-dimer levels with NSE (R = 0.727, P = 0.026) and sTF (R = 0.803, P = 0.009) levels. The blood level of d-dimer accurately reflects the degree of brain tissue damage indicated by NSE levels. Our data suggest that release of sTF induced by brain tissue damage may activate the coagulation cascade, leading to elevation of d-dimer.

Keywords: D-dimer; biomarker; neuron specific enolase; tissue factor; traumatic brain injury.

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Conflict of interest statement

Conflicts of Interest Disclosure

All authors have no conflicts of interest.

Figures

Fig. 1.
Fig. 1.
Changes in NSE and D-dimer concentrations in serum or plasma over the study period. The concentration of NSE and D-dimer was extremely high at admission, but decreased on the next day. Values are mean ± SEM. NSE: neuron specific enolase.
Fig. 2.
Fig. 2.
Linear regression curve of NSE and D-dimer levels in blood at admission. NSE: neuron specific enolase.
Fig. 3.
Fig. 3.
Linear regression curve of D-dimer and soluble tissue factor levels in blood at admission.
See this image and copyright information in PMC

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