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. 2020 May;34(9):1276-1281.
doi: 10.1080/14786419.2018.1560290. Epub 2019 Jan 24.

Acylated flavonoid glycosides from Barringtonia racemosa

Quach Thi Thanh Van  1   2 , Le Thi Vien  1 , Tran Thi Hong Hanh  1 , Phan Thi Thanh Huong  1 , Nguyen The Cuong  3 , Nguyen Phuong Thao  1 , Nguyen Huy Thuan  4 , Nguyen Hai Dang  1 , Nguyen Van Thanh  1 , Nguyen Xuan Cuong  1   2 , Nguyen Hoai Nam  1 , Phan Van Kiem  1 , Chau Van Minh  1
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Acylated flavonoid glycosides from Barringtonia racemosa

Quach Thi Thanh Van et al. Nat Prod Res. 2020 May.

Abstract

Using various chromatographic separations, three new acylated flavonoid glycosides, namely barringosides G-I (1-3), were isolated from the water-soluble extract of Barringtonia racemosa branches and leaves. The structure elucidation was performed by extensive analysis of the 1D and 2D NMR and HR-QTOF-MS data. Of the isolated compounds, barringoside I (3) showed moderate inhibitory effects on LPS-induced NO production in RAW264.7 cells with an IC50 of 52.48 ± 1.04 µM.

Keywords: Barringtonia racemosa; Lecythidaceae; NO production; flavonoid glycoside.

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