Immune responses to zoster vaccines

doi:10.1080/21645515.2018.1560918

Review

. 2019;15(4):772-777.

doi: 10.1080/21645515.2018.1560918. Epub 2019 Jan 24.

Immune responses to zoster vaccines

Myron J Levin^{1

2}, Adriana Weinberg^{1

2

3}

Affiliations

¹ a Departments of Pediatrics , University of Colorado Denver School of Medicine, Anschutz Medical Campus , Aurora , CO , USA.
² b Department of Medicine , University of Colorado Denver School of Medicine, Anschutz Medical Campus , Aurora , CO , USA.
³ c Department of Pathology , University of Colorado Denver School of Medicine, Anschutz Medical Campus , Aurora , CO , USA.

PMID: 30676834
PMCID: PMC6605864
DOI: 10.1080/21645515.2018.1560918

Review

Immune responses to zoster vaccines

Myron J Levin et al. Hum Vaccin Immunother. 2019.

. 2019;15(4):772-777.

doi: 10.1080/21645515.2018.1560918. Epub 2019 Jan 24.

Authors

Myron J Levin^{1

2}, Adriana Weinberg^{1

2

3}

Affiliations

¹ a Departments of Pediatrics , University of Colorado Denver School of Medicine, Anschutz Medical Campus , Aurora , CO , USA.
² b Department of Medicine , University of Colorado Denver School of Medicine, Anschutz Medical Campus , Aurora , CO , USA.
³ c Department of Pathology , University of Colorado Denver School of Medicine, Anschutz Medical Campus , Aurora , CO , USA.

PMID: 30676834
PMCID: PMC6605864
DOI: 10.1080/21645515.2018.1560918

Abstract

There are two licensed herpes zoster vaccines. One is a live vaccine (ZVL) based on an attenuated varicella-zoster virus (VZV). The other is a recombinant vaccine (RZV) based on the VZV glycoprotein E (gE) combined with AS01B, a multicomponent adjuvant system. RZV is superior to ZVL in efficacy, and differs from ZVL in that protection is not diminished by the age of the vaccinee and has not waned significantly during 4 years of follow-up. Immunologic studies demonstrated higher peak memory and persistence of T cell responses in RZV compared with ZVL recipients. RZV recipients also showed development and persistence of polyfunctional T cell responses. Taken together, we conclude that the immunologic data parallel and support the higher efficacy over time of RZV compared with ZVL.

Keywords: adjuvants; herpes zoster; immune responses; older adults; recombinant zoster vaccine; vaccinology; viral; zoster vaccine live.

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References

1. Gershon AA, Gershon MD.. Pathogenesis and current approaches to control of varicella-zoster virus infections. Clin Microbiol Rev. 2013;26:728–43. doi:10.1128/CMR.00052-13. - DOI - PMC - PubMed
1. Mitchell BM, Bloom DC, Cohrs RJ, Gilden DH, Kennedy PG. Herpes simplex virus-1 and varicella-zoster virus latency in ganglia. J Neurovirol. 2003;9:194–204. doi:10.1080/13550280390194000. - DOI - PubMed
1. Levin MJ, Cai GY, Manchak MD, Pizer LI. Varicella-zoster virus DNA in cells isolated from human trigeminal ganglia. J Virol. 2003;77:6979–87. - PMC - PubMed
1. Depledge DP, Ouwendijk WJD, Sadaoka T, Braspenning SE, Mori Y, Cohrs RJ, Verjans GMGM, Breuer J. A spliced latency-associated VZV transcript maps antisense to the viral transactivator gene 61. Nat Commun. 2018;9:1167. doi:10.1038/s41467-018-03569-2. - DOI - PMC - PubMed
1. Weinberg A, Levin MJ. VZV T cell-mediated immunity. Curr Top Microbiol Immunol. 2010;342:341–57. doi:10.1007/82_2010_31. - DOI - PubMed

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[1] Gershon AA, Gershon MD.. Pathogenesis and current approaches to control of varicella-zoster virus infections. Clin Microbiol Rev. 2013;26:728–43. doi:10.1128/CMR.00052-13. - DOI - PMC - PubMed

[2] Gershon AA, Gershon MD.. Pathogenesis and current approaches to control of varicella-zoster virus infections. Clin Microbiol Rev. 2013;26:728–43. doi:10.1128/CMR.00052-13. - DOI - PMC - PubMed

[3] Mitchell BM, Bloom DC, Cohrs RJ, Gilden DH, Kennedy PG. Herpes simplex virus-1 and varicella-zoster virus latency in ganglia. J Neurovirol. 2003;9:194–204. doi:10.1080/13550280390194000. - DOI - PubMed

[4] Mitchell BM, Bloom DC, Cohrs RJ, Gilden DH, Kennedy PG. Herpes simplex virus-1 and varicella-zoster virus latency in ganglia. J Neurovirol. 2003;9:194–204. doi:10.1080/13550280390194000. - DOI - PubMed

[5] Levin MJ, Cai GY, Manchak MD, Pizer LI. Varicella-zoster virus DNA in cells isolated from human trigeminal ganglia. J Virol. 2003;77:6979–87. - PMC - PubMed

[6] Levin MJ, Cai GY, Manchak MD, Pizer LI. Varicella-zoster virus DNA in cells isolated from human trigeminal ganglia. J Virol. 2003;77:6979–87. - PMC - PubMed

[7] Depledge DP, Ouwendijk WJD, Sadaoka T, Braspenning SE, Mori Y, Cohrs RJ, Verjans GMGM, Breuer J. A spliced latency-associated VZV transcript maps antisense to the viral transactivator gene 61. Nat Commun. 2018;9:1167. doi:10.1038/s41467-018-03569-2. - DOI - PMC - PubMed

[8] Depledge DP, Ouwendijk WJD, Sadaoka T, Braspenning SE, Mori Y, Cohrs RJ, Verjans GMGM, Breuer J. A spliced latency-associated VZV transcript maps antisense to the viral transactivator gene 61. Nat Commun. 2018;9:1167. doi:10.1038/s41467-018-03569-2. - DOI - PMC - PubMed

[9] Weinberg A, Levin MJ. VZV T cell-mediated immunity. Curr Top Microbiol Immunol. 2010;342:341–57. doi:10.1007/82_2010_31. - DOI - PubMed

[10] Weinberg A, Levin MJ. VZV T cell-mediated immunity. Curr Top Microbiol Immunol. 2010;342:341–57. doi:10.1007/82_2010_31. - DOI - PubMed

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Immune responses to zoster vaccines

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Immune responses to zoster vaccines

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