Levobunolol compared with timolol: a four-year study
- PMID: 3067745
- PMCID: PMC1041616
- DOI: 10.1136/bjo.72.12.892
Levobunolol compared with timolol: a four-year study
Abstract
Fifty-one patients with raised intraocular pressure (IOP) were treated for up to four years with one of three ophthalmic solutions: 0.5% levobunolol, 1% levobunolol, or 0.5% timolol. The study was conducted as a double-masked, randomised trial in which medications were administered twice daily to both eyes. Levobunolol and timolol were equally effective in reducing overall mean IOP; reductions were greater than 8.8 mmHg in all three treatment groups. The study showed levobunolol to be as safe and effective as timolol in the long-term control of raised IOP.
Similar articles
-
Efficacy and tolerability of 0.5% timolol maleate ophthalmic gel-forming solution QD compared with 0.5% levobunolol hydrochloride BID in patients with open-angle glaucoma or ocular hypertension.Clin Ther. 1998 Nov-Dec;20(6):1170-8. doi: 10.1016/s0149-2918(98)80112-4. Clin Ther. 1998. PMID: 9916610 Clinical Trial.
-
Levobunolol. A beta-adrenoceptor antagonist effective in the long-term treatment of glaucoma. The Levobunolol Study Group (Appended).Ophthalmology. 1985 Sep;92(9):1271-6. Ophthalmology. 1985. PMID: 2865710 Clinical Trial.
-
Glaucoma treatment with once-daily levobunolol.Am J Ophthalmol. 1986 Mar 15;101(3):298-304. doi: 10.1016/0002-9394(86)90823-8. Am J Ophthalmol. 1986. PMID: 3513594 Clinical Trial.
-
Comparison of ophthalmic beta-blocking agents.Clin Pharm. 1987 Jun;6(6):451-63. Clin Pharm. 1987. PMID: 2891463 Review.
-
Levobunolol for the long-term treatment of glaucoma.Gen Pharmacol. 1986;17(4):373-7. doi: 10.1016/0306-3623(86)90177-1. Gen Pharmacol. 1986. PMID: 3019819 Review.
Cited by
-
Pharmacological therapy for glaucoma: a review.Drugs. 2000 Mar;59(3):411-34. doi: 10.2165/00003495-200059030-00003. Drugs. 2000. PMID: 10776828 Review.
-
Visual field loss in patients with normal-tension glaucoma under topical nipradilol or timolol: subgroup and subfield analyses of the nipradilol-timolol study.Jpn J Ophthalmol. 2010 Jul;54(4):278-85. doi: 10.1007/s10384-010-0815-z. Epub 2010 Aug 11. Jpn J Ophthalmol. 2010. PMID: 20700793 Clinical Trial.
-
Management of glaucoma: focus on pharmacological therapy.Drugs Aging. 2005;22(1):1-21. doi: 10.2165/00002512-200522010-00001. Drugs Aging. 2005. PMID: 15663346 Review.
-
Medical interventions for primary open angle glaucoma and ocular hypertension.Cochrane Database Syst Rev. 2007 Oct 17;2007(4):CD003167. doi: 10.1002/14651858.CD003167.pub3. Cochrane Database Syst Rev. 2007. PMID: 17943780 Free PMC article.
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical